Palonosetron Side Effects
Some side effects of palonosetron may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to palonosetron: intravenous solution
Along with its needed effects, palonosetron may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking palonosetron:Less common
- Blurred vision
- chest pain or discomfort
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- irregular heartbeats that continue
- shortness of breath
- unusual tiredness or weakness
- Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site
- extra heartbeats
- pain in the shoulders, arms, jaw or neck
- pounding in the ears
- slow or fast heartbeat
Get emergency help immediately if any of the following symptoms of overdose occur while taking palonosetron:Symptoms of Overdose
- Bluish color of fingernails, lips, skin, palms, or nail beds
- gasping to breathe
- paleness of skin
Some side effects of palonosetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Difficulty having a bowel movement (stool)
- Abdominal pain
- acid or sour stomach
- bloated full feeling
- blood in urine
- bloody or black, tarry stools
- burning, crawling, itching, numbness, prickling, "pins and needles" , or tingling feelings
- change in vision
- continuing ringing or buzzing
- decrease in frequency of urination
- decrease in urine volume
- deep breathing
- difficult breathing
- difficulty in passing urine
- dry mouth
- excess air or gas in stomach or intestines
- excessive sleeping
- eye irritation
- feeling happy
- feeling of warmth
- flushed dry skin
- fruit-like breath odor
- general feeling of discomfort or illness
- hearing loss
- impaired vision
- increased hunger
- increased thirst
- increased urination
- joint pain
- large, flat, blue or purplish patches in the skin
- loss of appetite
- muscle aches and pains
- muscle tremors
- numbness or tingling in hands, feet, or lips
- painful knees and ankles
- painful urination
- passing gas
- raised red swellings on the skin, the buttocks, legs or ankles
- red, sore eyes
- redness of the face, neck, arms and occasionally, upper chest
- runny nose
- sore throat
- stomach discomfort, upset, or pain
- sugar in the urine
- swelling or protruding veins
- troubled breathing
- trouble sleeping
- unexplained noise in ears
- unexplained weight loss
- unusually deep sleep
- unusually long duration of sleep
- vein discoloration
- weakness or heaviness of legs
For Healthcare Professionals
Applies to palonosetron: intravenous solution, oral capsule
Cardiovascular side effects have been reported rarely. Bradycardia, hypotension, and nonsustained tachycardia have been reported in approximately 1% of patients in clinical trials. Hypertension, myocardial ischemia, extrasystoles, sinus tachycardia, sinus arrhythmia, supraventricular extrasystoles, and QT prolongation have been reported in less than 1% of patients. In many cases, causality was unclear.
Dermatological side effects including allergic dermatitis (less than 1%) and rash (less than 1%) have been rarely reported.
Gastrointestinal side effects have included constipation (2% to 5% or greater ) and diarrhea (1%). Appetite decrease, dyspepsia, abdominal pain, dry mouth, hiccups, and flatulence have been reported by less that 1% of patients in clinical trials.
General side effects have included reports of headache (2% to 9% or greater) and weakness (1%). Fatigue, fever, hot flash, and flu-like syndrome have been reported by less than 1% of patients in clinical trials.
Hepatic side effects occurred mainly in patients receiving highly emetogenic chemotherapy.
Hepatic side effects including transient, asymptomatic increases in AST and/or ALT and bilirubin have been reported in less than 1% of patients.
Metabolic side effects have included hyperkalemia (1%), electrolyte fluctuations, hyperglycemia, metabolic acidosis, and glycosuria.
Genitourinary side effects have included urinary retention (less than 1%).
Psychiatric side effects have included anxiety (1% to 2% or greater), anorexia (less than 1%), and euphoric mood (less than 1%).
Nervous system side effects including headache (2% to 9% or greater) and dizziness (1% to 2% or greater) have been reported. Insomnia, somnolence, hypersomnia, and paresthesia have been reported in less than 1% of patients.
Musculoskeletal side effects have rarely included arthralgia (less than 1%).
Ocular side effects including eye irritation and amblyopia have been reported in less than 1% of patients.
Local side effects have included very rare cases of injection site reactions (burning, induration, discomfort, and pain) during postmarketing experience.
Other side effects including fatigue and asthenia have been reported in greater than or equal to 2% of patients. Motion sickness, tinnitus, vein discoloration, and vein distention have been reported in less than 1% of patients.
More palonosetron resources
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