Palonosetron Side Effects

It is possible that some side effects of palonosetron may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to palonosetron: intravenous solution

As well as its needed effects, palonosetron may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking palonosetron, check with your doctor or nurse immediately:

Less common
  • Blurred vision
  • chest pain or discomfort
  • confusion
  • difficult breathing
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fainting
  • fever
  • irregular heartbeats that continue
  • sweating
  • unusual tiredness or weakness
Rare
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • extra heartbeats
  • nervousness
  • pain in the shoulders, arms, jaw, or neck
  • pounding in the ears
  • slow or fast heartbeat

If any of the following symptoms of overdose occur while taking palonosetron, get emergency help immediately:

Symptoms of overdose
  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • collapse
  • gasping to breathe
  • paleness of the skin
  • seizures

Some palonosetron side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Difficulty having a bowel movement (stool)
  • headache
Less common
  • Acid or sour stomach
  • belching
  • bloated or full feeling
  • blood in the urine
  • bloody or black, tarry stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • chills
  • continuing ringing or buzzing
  • cough
  • decrease in frequency of urination
  • decrease in urine volume
  • deep breathing
  • diarrhea
  • difficulty in passing urine
  • drowsiness
  • dry mouth
  • excess air or gas in the stomach or intestines
  • excessive sleeping
  • eye irritation
  • fear
  • feeling happy
  • feeling of warmth
  • flushed dry skin
  • fruit-like breath odor
  • general feeling of discomfort or illness
  • hearing loss
  • heartburn
  • hiccups
  • impaired vision
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • joint pain
  • large, flat, blue or purplish patches in the skin
  • loss of appetite
  • muscle aches and pains
  • muscle tremors
  • numbness or tingling in the hands, feet, or lips
  • painful knees and ankles
  • painful urination
  • passing gas
  • raised red swellings on the skin, the buttocks, legs or ankles
  • rash
  • red, sore eyes
  • redness of the face, neck, arms, and occasionally, upper chest
  • restlessness
  • runny nose
  • shivering
  • sore throat
  • stomach discomfort, upset, or pain
  • sugar in the urine
  • swelling or protruding veins
  • trembling
  • trouble sleeping
  • unexplained noise in the ears
  • unexplained weight loss
  • unusually deep sleep
  • unusually long duration of sleep
  • vein discoloration
  • weakness or heaviness of the legs

For Healthcare Professionals

Applies to palonosetron: intravenous solution, oral capsule

Cardiovascular

Common (1% to 10%): Bradycardia, hypotension, nonsustained tachycardia
Uncommon (0.1% to 1%): Hypertension, myocardial ischemia, extrasystoles, sinus tachycardia, sinus arrhythmia, supraventricular extrasystoles, QT prolongation

Dermatologic

Uncommon (0.1% to 1%): Allergic dermatitis, rash

Gastrointestinal

Common (1% to 10%): Constipation, diarrhea
Uncommon (0.1% to 1%): Appetite decrease, dyspepsia, abdominal pain, dry mouth, hiccups, flatulence

Hepatic

Uncommon (0.1% to 1%): Transient, asymptomatic increases in AST and/or ALT and bilirubin; increased transaminases

Metabolic

Common (1% to 10%): Hyperkalemia
Uncommon (0.1% to 1%): Electrolyte fluctuations, hyperglycemia, metabolic acidosis, glycosuria

Genitourinary

Uncommon (0.1% to 1%): Urinary retention

Psychiatric

Common (1% to 10%): Anxiety
Uncommon (0.1% to 1%): Euphoric mood

Nervous system

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Fatigue, fever, hot flash, insomnia, somnolence, hypersomnia, paresthesia

Musculoskeletal

Common (1% to 10%): Weakness
Uncommon (0.1% to 1%): Arthralgia

Ocular

Uncommon (0.1% to 1%): Eye irritation, amblyopia

Local

Very rare (less than 0.01%): Injection site reactions (burning, induration, discomfort, and pain)

Other

Uncommon (0.1% to 1%): Motion sickness, tinnitus, vein discoloration, vein distention, influenza-like syndrome

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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