Palonosetron Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced

Oral: 0.5 mg orally administered approximately 1 hour prior to the start of chemotherapy
Uses: Moderately emetogenic cancer chemotherapy: Prevention of acute nausea and vomiting associated with initial and repeat courses.

Parenteral: 0.25 mg IV as a single dose 30 minutes before the start of chemotherapy

Uses: Prevention of acute nausea and vomiting in adults associated with initial and repeat courses of moderately and highly emetogenic cancer chemotherapy.

Usual Adult Dose for Nausea/Vomiting - Postoperative

Parenteral: 0.075 mg IV as a single dose immediately before induction of anesthesia

Uses: Prevention of postoperative nausea and vomiting (PONV) in adults for up to 24 hours following surgery. Efficacy beyond 24 hours has not been determined.

Usual Pediatric Dose for Nausea/Vomiting - Chemotherapy Induced

Parenteral: 20 mcg/kg IV (maximum 1.5 mg x 1) infused over 15 minutes beginning 30 minutes before the start of chemotherapy

Uses: Prevention of acute nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including highly emetogenic cancer chemotherapy in patients 1 month to less than 17 years of age.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

-No dose adjustment is required in elderly patients.
-Experience with repeat dosing within a course of multi-day chemotherapy is limited.

Precautions

This drug may increase large bowel transit time; therefore, it is recommended to monitor patients with a history of constipation or signs of subacute intestinal obstruction following administration.

Safety and effectiveness have not been established in patients younger than 18 years.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug may be taken without regard to meals.
-This drug should be infused intravenously over 30 seconds.
-The IV infusion line should be flushed with normal saline before and after administration of this drug.

Storage requirements:
-This drug should be stored below 25 degrees Celsius and protected from light.

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