Generic Name: palonosetron (PAL oh NOE se tron)
Brand Names: Aloxi

What is Aloxi?

Aloxi (palonosetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Aloxi is used to prevent nausea and vomiting that may be caused by medicine to treat cancer (chemotherapy).

Aloxi may be used for other purposes not listed in this medication guide.

Important information

You should not use Aloxi if you are allergic to palonosetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or ondansetron (Zofran).

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Tell your doctor if you forget to take your dose within 1 hour before chemotherapy. Do not take extra medicine to make up the missed dose.

Before taking this medicine

You should not use Aloxi if you are allergic to palonosetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or ondansetron (Zofran). FDA pregnancy category B. Aloxi is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether palonosetron passes into breast milk or if it could harm a nursing baby. Do not use Aloxi without telling your doctor if you are breast-feeding a baby.

How should I take Aloxi?

Take Aloxi exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Aloxi is usually taken 1 hour before chemotherapy. Follow your doctor's instructions.

Store Aloxi at room temperature away from moisture and heat.

What happens if I miss a dose?

Tell your doctor if you forget to take your dose within 1 hour before chemotherapy. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

An overdose of Aloxi is not expected to produce life-threatening symptoms.

What should I avoid?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Aloxi side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Aloxi: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious Aloxiside effects may include:

  • headache;

  • constipation; or

  • tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Aloxi?

There may be other drugs that can interact with Aloxi. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Aloxi.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Aloxi only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 3.01. Revision Date: 01/11/2010 10:03:56 AM.

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