Nitro-Dur Side Effects

Generic Name: nitroglycerin

Note: This page contains side effects data for the generic drug nitroglycerin. It is possible that some of the dosage forms included below may not apply to the brand name Nitro-Dur.

It is possible that some side effects of Nitro-Dur may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to nitroglycerin: capsule extended release, spray, tablet, tablet extended release

As well as its needed effects, nitroglycerin (the active ingredient contained in Nitro-Dur) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking nitroglycerin, check with your doctor immediately:

Less common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • difficult or labored breathing
  • feeling faint, dizzy, or lightheadedness
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • headache
  • rapid weight gain
  • sweating
  • tightness in the chest
  • tingling of the hands or feet
  • unusual weight gain or loss
Rare
  • Bluish-colored lips, fingernails, or palms
  • dark urine
  • fever
  • pale skin
  • rapid heart rate
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Incidence not known
  • Arm, back, or jaw pain
  • blurred vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • cough
  • cracks in the skin
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • hives, itching, or rash
  • increased sweating
  • loss of heat from the body
  • nausea or vomiting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, swollen skin
  • redness of the face, neck, arms, and occasionally, upper chest
  • scaly skin
  • sensation of spinning
  • weakness

If any of the following symptoms of overdose occur while taking nitroglycerin, get emergency help immediately:

Symptoms of overdose
  • Bluish-colored lips, fingernails, or palms
  • blurred or loss of vision
  • bulging soft spot on the head of an infant
  • change in consciousness
  • change in the ability to see colors, especially blue or yellow
  • cold, clammy skin
  • dark urine
  • difficulty breathing
  • disturbed color perception
  • dizziness or lightheadedness
  • double vision
  • fever
  • flushed skin
  • halos around lights
  • headache, severe and throbbing
  • increased sweating
  • loss of appetite
  • loss of consciousness
  • night blindness
  • overbright appearance of lights
  • pale skin
  • paralysis
  • slow or irregular heartbeat
  • sore throat
  • tunnel vision
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some nitroglycerin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Abdominal or stomach pain
  • body aches or pain
  • congestion
  • hoarseness
  • lack or loss of strength
  • runny nose
  • sneezing
  • stuffy nose
  • tender, swollen glands in the neck
  • voice changes

For Healthcare Professionals

Applies to nitroglycerin: buccal tablet extended release, intravenous solution, oral capsule extended release, rectal ointment, sublingual spray, sublingual tablet, transdermal film extended release, transdermal ointment

General

The most common side effect is headache.[Ref]

Nervous system

Very common (10% or more): Headache (up to 64%)
Common (1% to 10%): Dizziness, lightheadedness, syncope, vertigo, drowsiness
Rare (0.1% to 0.01%): Severe and prolonged headache
Very rare (less than 0.01%): Cerebral ischemia
Frequency not reported: Faintness, somnolence[Ref]

Cardiovascular

Common (1% to 10%): Hypotension, angina increased, paradoxical bradycardia, tachycardia, orthostatic hypotension, blood pressure decreased, facial flushing
Uncommon (0.1 to 1%): Circulatory collapse
Rare (less than 0.1%): Bradycardia, cyanosis, flushing, heart rate increase
Frequency not reported: Crescendo angina, rebound hypertension, palpitations, hypertension, decreased arterial oxygen tension, severe arterial hypotension with bradycardia, transient flushing[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting
Rare (0.01% to 0.1%): Dry mouth
Very rare (less than 0.01%): Heartburn, halitosis
Frequency not reported: Abdominal pain, retching, lip and tongue swelling[Ref]

Dermatologic

Uncommon (0.1% to 1%): Dermatitis contact, erythema, pruritus, burning, irritation, eczema, urticaria
Rare (0.01 to 0.1%): Allergic skin reactions, rash
Very rare (less than 0.01%): Exfoliative dermatitis, drug rash
Frequency not reported: Cutaneous flushing, diaphoresis, angioedema
Postmarketing reports: Rash generalized[Ref]

Other

Common (1% to 10%): Asthenia, weakness
Frequency not reported: Retrosternal discomfort[Ref]

Hypersensitivity

Rare (less than 0.1%): Hypersensitivity reactions, anaphylaxis
Frequency not reported: Allergic reaction, anaphylactoid reaction[Ref]

Psychiatric

Common (1% to 10%): Restlessness
Frequency not reported: Apprehension[Ref]

Respiratory

Very rare (less than 0.01%): Impairment of respiration
Frequency not reported: Hypoxemia[Ref]

Hematologic

Very rare (less than 0.01%): Methemoglobinemia[Ref]

Ocular

Rare (less than 0.1%): Blurred vision
Frequency not reported: Increased ocular pressure[Ref]

Musculoskeletal

Frequency not reported: Muscle twitching[Ref]

References

1. "Product Information. Nitrolingual (nitroglycerin)." First Horizon Pharmaceutical Corporation, Alpharetta, GA.

2. "Product Information. Nitrostat (nitroglycerin)." Parke-Davis, Morris Plains, NJ.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. Cerner Multum, Inc. "Australian Product Information." O 0

5. "Product Information. Tridil (nitroglycerin)." DuPont Pharmaceuticals, Wilmington, DE.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web2)