Rectiv

Generic Name: nitroglycerin (rectal) (NYE troe GLIS er in)
Brand Names: Rectiv

What is Rectiv?

Rectiv Ointment contains nitroglycerin, a nitrate that dilates (widens) blood vessels.

Rectiv is used to treat moderate to severe pain caused by chronic anal fissures (tears in the skin lining your rectum).

Rectiv may also be used for purposes not listed in this medication guide.

Important information

You should not use Rectiv if you are allergic to nitroglycerin or any other nitrate medication. This includes isosorbide dinitrate (Dilatrate, Isordil, Isochron), isosorbide mononitrate (Imdur, ISMO, Monoket), or nitroglycerin used in a pill form or spray under the tongue, or as a skin patch or ointment (Minitran, Nitrek, Nitro-Bid, Nitro-Dur, Nitrolingual, Nitromist, Nitrostat, Nitro-Time, and others.)

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Do not use Rectiv if you are taking sildenafil (Viagra, Revatio), avanafil (Stendra), tadalafil (Cialis), or vardenafil (Levitra). Serious, life-threatening side effects can occur if you use Rectiv while you are using sildenafil. You also should not use Rectiv if you have: severe anemia (a lack of red blood cells), or a brain injury, hemorrhage, or tumor.

Before using Rectiv, tell your doctor if you have congestive heart failure, low blood pressure, glaucoma, liver disease, migraine headaches, or a history of heart attack, stroke, or circulation problems.

Do not use this medication without the advice of a doctor if you have early signs of a heart attack (chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling). Seek emergency medical attention if you have symptoms of a heart attack.

Rectiv can cause severe headaches, which may occur each time you use the medication. Your doctor may recommend treating fever and pain with an aspirin free pain reliever such as acetaminophen (Tylenol). Follow the label directions or your doctor's instructions about how much of this medicine to use.

Before using Rectiv

Do not use Rectiv if you are taking sildenafil (Viagra, Revatio), avanafil (Stendra), tadalafil (Cialis), or vardenafil (Levitra). Serious, life-threatening side effects can occur if you use Rectiv while you are using sildenafil. You should not use this medication if you are allergic to:

  • isosorbide dinitrate (Dilatrate, Isordil, Isochron);

  • isosorbide mononitrate (Imdur, ISMO, Monoket); or

  • nitroglycerin used in a pill form or spray under the tongue, or as a skin patch or ointment (Minitran, Nitrek, Nitro-Bid, Nitro-Dur, Nitrolingual, Nitromist, Nitrostat, Nitro-Time, and others).

You also should not use Rectiv if you have:

  • severe anemia (a lack of red blood cells); or

  • a brain injury, hemorrhage, or tumor.

Do not use Rectiv if you have early signs of a heart attack (chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling). Seek emergency medical attention if you have symptoms of a heart attack.

To make sure you can safely use Rectiv, tell your doctor if you have any of these other conditions:

  • congestive heart failure;

  • a history of heart attack, stroke, or circulation problems;

  • low blood pressure;

  • glaucoma;

  • migraine headaches; or

  • liver disease.

FDA pregnancy category C. It is not known whether Rectiv will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether nitroglycerin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give Rectiv to anyone under 18 years old without medical advice.

See also: Pregnancy and breastfeeding warnings (in more detail)

How should I use Rectiv?

Use Rectiv exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse while using nitroglycerin ointment. Do not use this medication for longer than 3 weeks unless your doctor tells you to.

Store Rectiv at room temperature away from moisture and heat. Keep the tube tightly closed when not in use. Throw away any Rectiv Ointment you have not used within 8 weeks after you first opened the tube.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fainting.

What should I avoid?

Nitroglycerin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. It can increase some of the side effects of nitroglycerin, such as dizziness, drowsiness, feeling light-headed, or fainting.

Rectiv side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Rectiv: hives, difficult breathing, swelling of your face, lips, tongue, or throat. Rectiv can cause severe headaches, which may occur each time you use the medication. Your doctor may recommend treating fever and pain with an aspirin free pain reliever such as acetaminophen (Tylenol). Follow the label directions or your doctor's instructions about how much of this medicine to use.

Less serious Rectiv side effects may include:

  • dizziness; or

  • mild headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Rectiv?

Many drugs can interact with nitroglycerin. Below is just a partial list. Tell your doctor if you are using:

  • alteplase (Activase);

  • aspirin or heparin;

  • dihydroergotamine (D.H.E. 45, Migranal) or ergotamine (Ergomar, Cafergot, and others);

  • heart or blood pressure medication such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), nebivolol (Bystolic), propranolol (Inderal, InnoPran), sotalol (Betapace), and others; or

  • nitroglycerin used in a pill form or spray under the tongue, or as a skin patch or skin ointment.

This list is not complete and there are many other drugs that can interact with nitroglycerin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about nitroglycerin.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Rectiv only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Copyright 1996-2014 Cerner Multum, Inc. Version: 1.01. Revision Date: 2012-08-14, 11:53:11 PM.

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