Invokana Side Effects

Generic Name: canagliflozin

Note: This page contains information about the side effects of canagliflozin. Some of the dosage forms included on this document may not apply to the brand name Invokana.

Not all side effects for Invokana may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to canagliflozin: oral tablet

In addition to its needed effects, some unwanted effects may be caused by canagliflozin (the active ingredient contained in Invokana). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking canagliflozin:

More common
  • Bladder pain
  • bloody or cloudy urine
  • decreased frequency or amount of urine
  • difficult, burning, or painful urination
  • discharge with a strong odor from the penis
  • frequent urge to urinate
  • increased blood pressure
  • increased thirst
  • itching of the vagina or outside of the genitals
  • loss of appetite
  • lower back or side pain
  • nausea
  • pain during sexual intercourse
  • pain in the skin around the penis
  • redness, itching, or swelling of the penis
  • swelling of the face, fingers, or lower legs
  • troubled breathing
  • unusual tiredness or weakness
  • vaginal discharge without odor or with mild odor
  • vomiting
  • weight gain
Less common
  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • confusion
  • cool, pale skin
  • depression
  • dizziness
  • dry mouth
  • fast or irregular heartbeat
  • headache
  • hives or welts
  • increased hunger
  • itching skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nightmares
  • rash
  • redness of the skin
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness
Incidence not known
  • Abdominal or stomach pain
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • numbness or tingling in the hands, feet, or lips
  • sweating
  • weakness or heaviness of the legs

Some of the side effects that can occur with canagliflozin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Difficulty having a bowel movement (stool)
  • lack or loss of strength
  • pain or swelling in the arms or legs without an injury
Rare
  • Increased sensitivity of the skin to sunlight
  • redness or other discoloration of the skin
  • severe sunburn

For Healthcare Professionals

Applies to canagliflozin: oral tablet

General

Most common adverse reactions include female genital mycotic infections, urinary tract infection, and increased urination.

Cardiovascular

Frequency not reported: Intravascular volume depletion, hypotension, orthostatic hypotension

Dermatologic

Uncommon (0.1% to 1%): Photosensitivity reaction, polymorphic light eruption, sunburn

Endocrine

Frequency not reported: Hypoglycemia

Gastrointestinal

Common (1% to 10%): Thirst (dry mouth, polydipsia), constipation, nausea, abdominal pain

Genitourinary

Very common (10% or more): Female genital mycotic infections (vulvovaginal candidiasis, vulvovaginal mycotic infection, vulvovaginitis, vaginal infection, vulvitis, and genital fungal infection)
Common (1% to 10%): Urinary tract infections (cystitis, kidney infection, urosepsis), increased urination (polyuria, pollakiuria, urine output increased, micturition urgency, nocturia), male genital mycotic infections (blanitis or balanoposthitis, balanitis candida, genital fungal infection), vulvovaginal pruritus
Uncommon (0.1% to 1%): Phimosis (uncircumcised men)
Frequency not reported: Osmotic diuresis

Hematologic

Common (1% to 10%): Increased hemoglobin

Hypersensitivity

Common (1% to 10%): Erythema, rash, pruritus, urticaria, angioedema

Metabolic

Common (1% to 10%): Increased serum potassium
Frequency not reported: Dehydration, increased serum magnesium, increased serum phosphate, increased low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C)

Musculoskeletal

Uncommon (0.1% to 1%): Loss of strength or energy (asthenia), bone fractures
Frequency not reported: Upper extremity fractures

Nervous system

Frequency not reported: Syncope, postural dizziness

Other

Common (1% to 10%): Fatigue

Renal

Frequency not reported: Increased serum creatinine, decreased glomerular filtration rate (GFR), renal function decline, renal impairment, acute renal failure

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web4)