Invokana Side Effects

Generic Name: canagliflozin

Note: This page contains side effects data for the generic drug canagliflozin. It is possible that some of the dosage forms included below may not apply to the brand name Invokana.

It is possible that some side effects of Invokana may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to canagliflozin: oral tablet

As well as its needed effects, canagliflozin (the active ingredient contained in Invokana) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking canagliflozin, check with your doctor immediately:

More common
  • Bladder pain
  • bloody or cloudy urine
  • decreased frequency or amount of urine
  • difficult, burning, or painful urination
  • discharge with a strong odor from the penis
  • frequent urge to urinate
  • increased blood pressure
  • increased thirst
  • itching of the vagina or outside of the genitals
  • loss of appetite
  • lower back or side pain
  • nausea
  • pain during sexual intercourse
  • pain in the skin around the penis
  • redness, itching, or swelling of the penis
  • swelling of the face, fingers, or lower legs
  • troubled breathing
  • unusual tiredness or weakness
  • vaginal discharge without odor or with mild odor
  • vomiting
  • weight gain
Less common
  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • confusion
  • cool, pale skin
  • depression
  • dizziness
  • dry mouth
  • fast or irregular heartbeat
  • headache
  • hives or welts
  • increased hunger
  • itching skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nightmares
  • rash
  • redness of the skin
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness
Incidence not known
  • Abdominal or stomach pain
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • numbness or tingling in the hands, feet, or lips
  • sweating
  • weakness or heaviness of the legs

Some canagliflozin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Difficulty having a bowel movement (stool)
  • lack or loss of strength
  • pain or swelling in the arms or legs without an injury
  • Increased sensitivity of the skin to sunlight
  • redness or other discoloration of the skin
  • severe sunburn

For Healthcare Professionals

Applies to canagliflozin: oral tablet


Most common adverse reactions include female genital mycotic infections, urinary tract infection, and increased urination.


Frequency not reported: Intravascular volume depletion, hypotension, orthostatic hypotension


Uncommon (0.1% to 1%): Photosensitivity reaction, polymorphic light eruption, sunburn


Frequency not reported: Hypoglycemia


Common (1% to 10%): Thirst (dry mouth, polydipsia), constipation, nausea, abdominal pain


Very common (10% or more): Female genital mycotic infections (vulvovaginal candidiasis, vulvovaginal mycotic infection, vulvovaginitis, vaginal infection, vulvitis, and genital fungal infection)
Common (1% to 10%): Urinary tract infections (cystitis, kidney infection, urosepsis), increased urination (polyuria, pollakiuria, urine output increased, micturition urgency, nocturia), male genital mycotic infections (blanitis or balanoposthitis, balanitis candida, genital fungal infection), vulvovaginal pruritus
Uncommon (0.1% to 1%): Phimosis (uncircumcised men)
Frequency not reported: Osmotic diuresis


Common (1% to 10%): Increased hemoglobin


Common (1% to 10%): Erythema, rash, pruritus, urticaria, angioedema


Common (1% to 10%): Increased serum potassium
Frequency not reported: Dehydration, increased serum magnesium, increased serum phosphate, increased low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C)


Uncommon (0.1% to 1%): Loss of strength or energy (asthenia), bone fractures
Frequency not reported: Upper extremity fractures

Nervous system

Frequency not reported: Syncope, postural dizziness


Common (1% to 10%): Fatigue


Frequency not reported: Increased serum creatinine, decreased glomerular filtration rate (GFR), renal function decline, renal impairment, acute renal failure

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