Hylorel Side Effects
Generic Name: guanadrel
Note: This page contains information about the side effects of guanadrel. Some of the dosage forms included on this document may not apply to the brand name Hylorel.
Not all side effects for Hylorel may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to guanadrel: oral tablet
In addition to its needed effects, some unwanted effects may be caused by guanadrel (the active ingredient contained in Hylorel). In the event that any of these side effects do occur, they may require medical attention.
If any of the following symptoms of overdose occur while taking guanadrel, get emergency help immediately:Rare
- Blurred vision
- dizziness or faintness (severe)
If any of the following side effects occur while taking guanadrel, check with your doctor or nurse as soon as possible:More common
- Swelling of feet or lower legs
- Chest pain
- shortness of breath
Some of the side effects that can occur with guanadrel may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
- Difficulty in ejaculating
- dizziness, lightheadedness, or fainting, especially when getting up from a lying or sitting position
- unusual tiredness or weakness
- weight gain or loss (excessive)
- Diarrhea or increase in bowel movements
- dryness of mouth
- muscle pain or tremors
- nighttime urination
For Healthcare Professionals
Applies to guanadrel: oral tablet
The most common problems associated with guanadrel (the active ingredient contained in Hylorel) affect the nervous system. Up to 60% of patients have experienced drowsiness, fatigue, or headaches, 25% of patients experienced paresthesias or visual disturbances, and 2% experienced sleep disorders during therapy[Ref]
Cardiovascular side effects can result from excessive sympathetic blockade or a relative increase in parasympathetic tone. Orthostatic hypotension occurs in 8% to 50% of patients, some of whom experience syncope.
Unopposed or excessive parasympathetic tone can cause excessive bradycardia in rare cases. This may cause serious problems in patients with underlying sinus node dysfunction.
Peripheral edema has been reported in up to 30% of patients.
Other cardiovascular problems include chest pain in 28%, dyspnea at rest in 18%, dyspnea on exertion in 46%, and palpitations in 30% of patients. Underlying diseases may account for the relatively high incidence of some of these side effects.[Ref]
The risk of orthostatic hypotension, sometimes followed by syncope, is greatest within the first 10 minutes after dosing or early in the morning, and in hypovolemia. It is accentuated by alcohol, hot weather, or exercise--all of which are associated with peripheral vasodilation. The manufacturer recommends that guanadrel be gradually withdrawn over at least two weeks prior to administration of general anesthetics to avoid cardiovascular collapse during induction.[Ref]
Gastrointestinal side effects are also related to increased parasympathetic tone. Diarrhea has been reported in 5% to 30% of patients, some of whom discontinue therapy because of it. Constipation has been reported in up to 21% of patients. Dry mouth or parotid tenderness have been associated with the use of this drug in approximately 2% of patients.[Ref]
There is evidence that peripherally-acting antiadrenergic drugs may interfere with ejaculation by inhibiting contraction of the seminal vesicle, ampula and ductus deferens.[Ref]
Sexual impotence is a relatively common genitourinary complaint, occurring in 5% to 18% of male patients. Smaller studies, where specific questions were asked, revealed an incidence of impotence as high as 60% of male patients who were receiving a similar drug, guanethidine. Impotence appears to be reversible upon discontinuation of therapy or reduction in dosage. Urinary frequency or urgency has occurred in 30% to 50% of patients.[Ref]
Musculoskeletal cramping has occurred in approximately 20% to 40% of patients.[Ref]
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2. Hansson L, Pascual A, Julius S "Comparison of guanadrel and guanethidine." Clin Pharmacol Ther 14 (1973): 204-8
3. Bloomfield DK, Cangiano JL "Guanadrel and guanethidine in hypertension." Clin Pharmacol Ther 11 (1970): 200-4
4. Finnerty FA, Jr Brogden RN "Guanadrel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in hypertension." Drugs 30 (1985): 22-31
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6. Palmer JD, Nugent CA "Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension." Pharmacotherapy 3 (1983): 220-9
7. Dunn MI, Dunlap JL "Guanadrel. A new antihypertensive drug." JAMA 245 (1981): 1639-42
8. "Product Information. Hylorel (guanadrel)." Rhone-Poulenc Rorer, Collegeville, PA.
9. Bloomfield DK, Cangiano JL "Clinical experience with a new antihypertensive agent, guanadrel sulfate." Curr Ther Res Clin Exp 11 (1969): 727-35
10. "Guanadrel (Hylorel)--a new antihypertensive drug." Med Lett Drugs Ther 25 (1983): 95-6
11. Hogikyan RV, Supiano MA "Homologous upregulation of human arterial alpha-adrenergic responses by guanadrel." J Clin Invest 91 (1993): 1429-35
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13. Malinow SH "Comparison of guanadrel and guanethidine efficacy and side effects." Clin Ther 5 (1983): 284-9
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