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Hydrochlorothiazide / losartan Side Effects

Medically reviewed by Drugs.com. Last updated on May 12, 2023.

Applies to hydrochlorothiazide / losartan: oral tablet.

Warning

Oral route (Tablet)

Drugs that act directly on the renin-angiotensin system can cause injury or death to the developing fetus. Stop therapy as soon as possible when pregnancy is detected.

Serious side effects

Along with its needed effects, hydrochlorothiazide/losartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / losartan:

Rare

Incidence not known

Other side effects

Some side effects of hydrochlorothiazide / losartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Rare

Incidence not known

For Healthcare Professionals

Applies to hydrochlorothiazide / losartan: oral tablet.

General

The most common adverse reaction was dizziness.[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Losartan:

Frequency not reported: Syncope, cerebrovascular accident, ataxia, hypesthesia, memory impairment, migraine, paresthesia, peripheral neuropathy, somnolence, vertigo, tremor, taste perversion, tinnitus[Ref]

Respiratory

Common (1% to 10%): Cough, sinusitis, upper respiratory infection, bronchitis, pharyngitis

Hydrochlorothiazide:

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema

Losartan:

Frequency not reported: Dyspnea, epistaxis, nasal congestion, pharyngeal discomfort, respiratory congestion, rhinitis, sinus disorder

Postmarketing reports: Dry cough[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, diarrhea, nausea

Hydrochlorothiazide:

Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation

Losartan:

Frequency not reported: Constipation, dental pain, dry mouth, dyspepsia, flatulence, gastritis, vomiting[Ref]

Cardiovascular

Common (1% to 10%): Palpitation, essential hypertension

Uncommon (0.1% to 1%): Hypotension

Hydrochlorothiazide:

Frequency not reported: Vasculitis

Losartan:

Frequency not reported: Angina pectoris, arrhythmias, atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation, hypotension, myocardial infarction, second degree atrioventricular block, flushing

Postmarketing reports: Vasculitis[Ref]

Other

Common (1% to 10%): Edema/swelling, asthenia/fatigue

Hydrochlorothiazide:

Frequency not reported: Weakness, fever

Losartan:

Frequency not reported: Chest pain, facial edema, fever, orthostatic effects, malaise[Ref]

Dermatologic

Common (1% to 10%): Rash

Hydrochlorothiazide:

Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis

Losartan:

Common (1% to 10%): Rash

Frequency not reported: Angioedema, superficial peeling of palms, alopecia, dermatitis, dry skin, ecchymosis, erythema, photosensitivity, pruritus, sweating, urticaria

Postmarketing reports: Erythroderma[Ref]

Musculoskeletal

Common (1% to 10%): Back pain

Hydrochlorothiazide:

Frequency not reported: Muscle spasm

Losartan:

Frequency not reported: Arm pain, arthralgia, arthritis, fibromyalgia, hip pain, joint swelling, knee pain, leg pain, muscle cramps, muscle weakness, musculoskeletal pain, myalgia, shoulder pain, stiffness

Postmarketing reports: Rhabdomyolysis[Ref]

Renal

Uncommon (0.1% to 1%): Serum creatinine increased greater than 5 mg/dL, BUN increased

Hydrochlorothiazide:

Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis

Losartan:

Common (1% to 10%): Serum creatinine increased greater than 5 mg/dL[Ref]

Hepatic

Frequency not reported: Liver enzymes elevated, serum bilirubin elevated

Postmarketing reports: Hepatitis

Hydrochlorothiazide:

Frequency not reported: Intrahepatic cholestatic jaundice

Losartan:

Postmarketing reports: Hepatitis[Ref]

Hematologic

Frequency not reported: Hemoglobin decreased, hematocrit decreased

Hydrochlorothiazide:

Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia

Losartan:

Frequency not reported: Hemolysis, anemia[Ref]

Metabolic

Postmarketing reports: Hyperkalemia

Hydrochlorothiazide:

Frequency not reported: Hyperglycemia, hyperuricemia

Losartan:

Frequency not reported: Anorexia, gout

Postmarketing reports: Hyperkalemia, hyponatremia[Ref]

Ocular

Hydrochlorothiazide:

Frequency not reported: Transient blurred vision, xanthopsia

Losartan:

Frequency not reported: Blurred vision, burning/stinging in the eye, conjunctivitis, visual acuity decreased[Ref]

Psychiatric

Hydrochlorothiazide:

Frequency not reported: Restlessness

Losartan:

Frequency not reported: Anxiety, anxiety disorder, confusion, dream abnormality, depression, insomnia, libido decreased, nervousness, panic disorder, sleep disorder[Ref]

Genitourinary

Hydrochlorothiazide:

Frequency not reported: Glycosuria

Losartan:

Frequency not reported: Impotence, nocturia, urinary frequency, urinary tract infection[Ref]

Immunologic

Losartan:

Postmarketing reports: Anaphylactic reactions[Ref]

References

1. Product Information. Hyzaar (hydrochlorothiazide-losartan). Merck & Co., Inc. 2022.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.