Enduron Side Effects

Generic Name: methyclothiazide

Note: This page contains information about the side effects of methyclothiazide. Some of the dosage forms included on this document may not apply to the brand name Enduron.

Not all side effects for Enduron may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to methyclothiazide: oral tablet

Along with its needed effects, methyclothiazide (the active ingredient contained in Enduron) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methyclothiazide:

Incidence not known
  • Abdominal or stomach pain
  • back, leg, or stomach pains
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of skin
  • bloating
  • blood in urine or stools
  • bloody urine
  • blue lips and fingernails
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • clay-colored stools
  • cloudy urine
  • cold sweats
  • confusion
  • constipation
  • cough or hoarseness
  • coughing that sometimes produces a pink frothy sputum
  • coughing up blood
  • cracks in the skin
  • darkened urine
  • decrease in urine output or decrease in urine-concentrating ability
  • decreased frequency or amount of urine
  • diarrhea
  • difficult, fast, or noisy breathing, sometimes with wheezing
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position
  • dry mouth
  • fast or irregular heartbeat
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • general body swelling
  • general feeling of discomfort or illness
  • general feeling of tiredness or weakness
  • greatly decreased frequency of urination or amount of urine
  • headache
  • hives
  • increased blood pressure
  • increased hunger
  • increased sweating
  • increased thirst
  • increased urination
  • indigestion
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • loss of heat from the body
  • lower back or side pain
  • muscle cramps or pain
  • nausea or vomiting
  • nosebleeds
  • numbness, tingling, pain, or weakness in hands or feet
  • pain in joints or muscles
  • painful or difficult urination
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • pinpoint red spots on skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • red, swollen skin
  • redness, soreness, or itching skin
  • scaly skin
  • seizures
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • sores, welting or blisters
  • sugar in the urine
  • swelling of face, fingers, legs, ankles, feet, or lower legs
  • swollen or painful glands
  • tenderness of salivary glands
  • thickening of bronchial secretions
  • tightness in chest
  • trembling
  • troubled breathing
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight loss
  • vomiting of blood
  • weakness and heaviness of legs
  • weight gain
  • wheezing
  • yellow eyes or skin

Some side effects of methyclothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Cramping
  • decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • feeling of constant movement of self or surroundings
  • hair loss, thinning of hair
  • inability to have or keep an erection
  • increased sensitivity of skin to sunlight
  • loss in sexual ability, desire, drive, or performance
  • muscle spasm
  • pinpoint red or purple spots on skin
  • redness or other discoloration of skin
  • restlessness
  • sensation of spinning
  • severe sunburn
  • weakness

For Healthcare Professionals

Applies to methyclothiazide: compounding powder, oral tablet

Metabolic

Metabolic changes associated with methyclothiazide (the active ingredient contained in Enduron) as with other thiazide diuretics, are relatively common, especially when daily doses greater than 5 mg are used. Mild hypokalemia (decrease of 0.5 mEq/L) occurs in up to 50% of treated patients. Hypokalemia may predispose patients to cardiac arrhythmias. Metabolic alkalosis, hyponatremia, hypomagnesemia, hypophosphatemia, hypercalcemia, hyperglycemia, hypercholesterolemia, and hyperuricemia are also relatively common. The electrolyte and intravascular fluid shifts that may occur during methyclothiazide diuresis can provoke hepatic encephalopathy or coma in patients with hepatic cirrhosis.

Hyperuricemia may be an important consideration in patients with a history of gout. Hypophosphatemia and low serum magnesium concentrations may occur, but are usually clinically insignificant except in malnourished patients.

Cardiovascular

Cardiovascular complications of diuretic therapy include orthostatic hypotension secondary to intravascular volume depletion. This has resulted in syncope and, in some patients with glaucoma, temporary loss of vision. Rare cases of cerebrovascular accident associated with thiazide-induced diuresis have been reported.

Orthostatic hypotension associated with methyclothiazide may be potentiated by concomitant use of alcohol, barbiturates, or narcotics.

Hypersensitivity

Thiazides may induce allergic reactions in patients who are allergic to sulfonamides.

Hypersensitivity reactions usually involve the skin (cutaneous vasculitis, urticaria, rash, purpura), but may involve the gastrointestinal system (nausea, vomiting, or diarrhea), the genitourinary system (interstitial nephritis), and the respiratory system (acute noncardiogenic pulmonary edema, pneumonitis). Thiazide diuretics may induce phototoxic dermatitis.

Dermatologic

Dermatologic reactions may indicate hypersensitivity to the drug. Erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis (including toxic epidermal necrolysis), and alopecia have been reported in rare cases.

Gastrointestinal

Gastrointestinal problems include diarrhea, vomiting, constipation, or abdominal pain in approximately 5% of patients. Thiazide diuretics have been associated with acute cholecystitis and rare cases of pancreatitis, sialadenitis, and anorexia.

A retrospective case-controlled drug surveillance study has revealed the relative risk of acute cholecystitis associated with the use of a thiazide diuretic is 2.0. The suspected explanation for this association is the potentially deleterious effect thiazides have on the serum lipid profile. Methyclothiazide-induced hypercholesterolemia or hypertriglyceridemia may enhance the formation of some types of gallstones.

Renal

Renal side effects including new or worsened renal insufficiency associated with methyclothiazide (the active ingredient contained in Enduron) therapy is a probable sign of intravascular volume depletion and serves as a signal to reduce or withhold therapy. Rare cases of allergic interstitial nephritis have been associated with some thiazide diuretics.

Endocrine

Endocrinologic changes associated with methyclothiazide (the active ingredient contained in Enduron) as with other thiazide diuretic agents, include decreased glucose tolerance and a potentially deleterious effect on the lipid profile. This may be important in patients with, or who are at risk for, diabetes or coronary artery disease.

Hematologic

Hematologic side effects are rare. Rare cases of immune-complex hemolytic anemia, aplastic anemia, leukopenia, and thrombocytopenia have been associated with methyclothiazide (the active ingredient contained in Enduron) or other thiazide diuretics.

Nervous system

Nervous system side effects include vertigo, paresthesias, and restlessness.

Musculoskeletal

Musculoskeletal cramping or spasms are occasionally reported during thiazide diuresis.

Genitourinary

Genitourinary problems are limited to rare complaints of impotence among male patients.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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