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Methyclothiazide

Generic Name: methyclothiazide (meth-i-kloe-THYE-a-zide)
Brand Name: Generic only. No brands available.

Methyclothiazide is used for:

Treating excess fluid buildup in the body caused by certain conditions or medicines. It may also be used to treat high blood pressure or other conditions as determined by your doctor.

Methyclothiazide is a thiazide diuretic. It works by helping the kidneys eliminate fluid from the body. Exactly how methyclothiazide works to treat high blood pressure is unknown.

Do NOT use methyclothiazide if:

  • you are allergic to any ingredient in methyclothiazide or to any other sulfonamide medicine (eg sulfamethoxazole, glyburide, acetazolamide)
  • you are unable to urinate
  • you are taking dofetilide or ketanserin

Contact your doctor or health care provider right away if any of these apply to you.

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Before using methyclothiazide:

Some medical conditions may interact with methyclothiazide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have gout, kidney or liver problems, lupus, diabetes, asthma, parathyroid problems, high blood cholesterol or lipid levels, or low blood pressure
  • if you have low blood sodium, chloride, potassium, or magnesium levels; or high blood calcium levels
  • if you have recently had nerve surgery

Some MEDICINES MAY INTERACT with methyclothiazide. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nonsteroidal anti-inflammatory medicines (NSAIDs) (eg, ibuprofen) because they decrease the effectiveness of methyclothiazide
  • Adrenocorticotropic hormone (ACTH), barbiturates (eg, phenobarbital), corticosteroids (eg, prednisone), narcotic pain medicines (eg, codeine, morphine, fentanyl), or medicines for high blood pressure because side effects of methyclothiazide may be increased
  • Diazoxide or nondepolarizing muscle relaxants (eg, tubocurarine) because side effects may be increased by methyclothiazide
  • Lithium because risk of toxicity may be increased by methyclothiazide
  • Digoxin, dofetilide, or ketanserin because risk of irregular heartbeat may be increased by methyclothiazide
  • Diabetes medicines (eg, glipizide, metformin) or insulin because their effectiveness may be decreased by methyclothiazide

This may not be a complete list of all interactions that may occur. Ask your health care provider if methyclothiazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use methyclothiazide:

Use methyclothiazide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Methyclothiazide may be taken with or without food.
  • When you first start taking methyclothiazide, it may cause an increase in urine or in frequency of urination. To prevent this from affecting sleep, try not to take any dose later than 6 pm.
  • Continue to use methyclothiazide even if you feel well. Do not miss any doses.
  • If you miss a dose of methyclothiazide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use methyclothiazide.

Important safety information:

  • Methyclothiazide may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to methyclothiazide. Using methyclothiazide alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Methyclothiazide may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using methyclothiazide.
  • Methyclothiazide may cause high blood sugar (eg, thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor). If these symptoms occur, tell your doctor immediately.
  • Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.
  • Methyclothiazide may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to methyclothiazide. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
  • Patients being treated for high blood pressure often feel tired or run down for a few weeks after beginning therapy. Continue taking your medication even though you may not feel quite "normal." Contact your doctor or pharmacist about any new symptoms.
  • Methyclothiazide may interfere with certain LAB TESTS. Make sure your doctor and laboratory personnel know you are using methyclothiazide.
  • LAB TESTS, including kidney function, blood pressure, and blood electrolyte levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use methyclothiazide with caution in the ELDERLY because they may be more sensitive to its effects.
  • Use methyclothiazide with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using methyclothiazide during pregnancy. Methyclothiazide is excreted in breast milk. Do not breast-feed while taking methyclothiazide.

Possible side effects of methyclothiazide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; headache; lightheadedness, especially when sitting up or standing; numbness or tingling of skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloating; confusion; decrease in amount of urine; drowsiness; gout; inability to keep an erection; inflammation of the pancreas; muscle pain or cramps; nausea; rapid or irregular heartbeat; red, swollen, blistered, or peeling skin; restlessness; seizures; severe stomach pain; shortness of breath; unusual thirst; unusual tiredness or weakness; unusually dry mouth; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; dry mouth; excessive urination followed by a decrease in amount of urine; muscle cramps; muscle weakness; severe lightheadedness, especially upon standing; weak or irregular heartbeat.

Proper storage of methyclothiazide:

Store methyclothiazide at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep methyclothiazide out of the reach of children and away from pets.

General information:

  • If you have any questions about methyclothiazide, please talk with your doctor, pharmacist, or other health care provider.
  • Methyclothiazide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take methyclothiazide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about methyclothiazide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to methyclothiazide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using methyclothiazide.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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