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Daypro Side Effects

Generic Name: oxaprozin

Note: This page contains information about the side effects of oxaprozin. Some of the dosage forms included on this document may not apply to the brand name Daypro.

In Summary

More frequent side effects include: diarrhea, constipation, dyspepsia, skin rash, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to oxaprozin: oral tablet

In addition to its needed effects, some unwanted effects may be caused by oxaprozin (the active ingredient contained in Daypro). In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking oxaprozin:

More common:
  • Skin rash
Less common:
  • Bloating
  • bloody or black, tarry stools
  • burning upper abdominal pain
  • burning while urinating
  • cloudy urine
  • constipation
  • decrease in urine output or decrease in urine-concentrating ability
  • diarrhea
  • difficult or painful urination
  • frequent urination
  • headache
  • heartburn
  • indigestion
  • itching skin
  • loss of appetite
  • nausea or vomiting
  • pale skin
  • severe abdominal pain, cramping, or burning
  • severe and continuing nausea
  • swelling
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weight loss
  • Agitation
  • bleeding gums
  • blistering, peeling, loosening of skin
  • blurred vision
  • body aches or pain
  • burning feeling in chest or stomach
  • changes in blood pressure
  • chest pain
  • clay-colored stools
  • coma
  • confusion
  • cough or hoarseness
  • cracks in the skin
  • dark urine
  • depression
  • difficult or labored breathing
  • difficulty swallowing
  • dilated neck veins
  • dizziness
  • ear congestion
  • extreme fatigue
  • fainting
  • feeling of discomfort
  • fever or chills
  • fluid-filled skin blisters
  • high fever
  • hives or welts
  • hostility
  • increased sensitivity of skin to sunlight
  • increased thirst
  • increased volume of pale, dilute urine
  • inflammation of joints
  • irregular, fast or slow, or shallow breathing
  • irritability
  • joint or muscle pain
  • large, flat, blue or purplish patches in the skin
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • light-colored stools
  • lightheadedness
  • loss of heat from the body
  • loss of voice
  • lower back or side pain
  • muscle aches
  • muscle twitching
  • nasal congestion
  • nervousness
  • noisy breathing
  • pain or burning in throat
  • pain or tenderness around eyes and cheekbones
  • pale or blue lips, fingernails, or skin
  • pinpoint red or purple spots on skin
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness or other discoloration of skin
  • redness, swelling, or soreness of tongue
  • scaly skin
  • seizures
  • severe sunburn
  • shortness of breath
  • skin thinness
  • slow, fast, irregular, pounding, or racing heartbeat or pulse
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on lips or tongue or inside the mouth
  • stomach upset
  • stuffy or runny nose
  • stupor
  • swelling of face, fingers, feet, or lower legs
  • swelling or inflammation of the mouth
  • swollen lymph glands
  • tenderness in stomach area
  • tightness in chest
  • unpleasant breath odor
  • upper right abdominal pain
  • wheezing
  • yellow eyes or skin

Severity: Minor

Some of the side effects that can occur with oxaprozin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Acid or sour stomach
  • belching
  • stomach discomfort
Less common:
  • Continuing ringing or buzzing or other unexplained noise in ears
  • excess air or gas in stomach or intestines
  • hearing loss
  • passing gas
  • relaxed and calm
  • sleepiness or unusual drowsiness
  • trouble sleeping
  • Anxiety
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, dry, or itching eyes
  • change in taste
  • decreased hearing
  • discharge, excessive tearing
  • dry mouth
  • feeling of constant movement of self or surroundings
  • general feeling of discomfort or illness
  • lack or loss of strength
  • redness, pain, swelling of eye, eyelid, or inner lining of eyelid
  • sensation of spinning
  • shakiness in legs, arms, hands, feet
  • sleeplessness
  • trembling or shaking of hands or feet
  • unable to sleep

For Healthcare Professionals

Applies to oxaprozin: oral tablet


The most frequently reported adverse effects were gastrointestinal (GI) in nature and included GI pain, anorexia, GI ulcers, heartburn, dyspepsia, nausea, vomiting, diarrhea, constipation, flatulence, and gross bleeding or perforation.[Ref]


Common (1% to 10%): Abdominal pain/distress, anorexia, constipation, diarrhea, dyspepsia, flatulence, gastrointestinal (GI) ulcers, gross bleeding/perforation, heartburn, nausea, vomiting
Frequency not reported: Dry mouth, eructation, esophagitis, gastritis, glossitis, hematemesis, stomatitis, pancreatitis, hemorrhoid bleeding, rectal bleeding, melena[Ref]


Common (1% to 10%): Liver enzymes elevated
Frequency not reported: Jaundice, liver function abnormalities, hepatitis, liver failure[Ref]


Common (1% to 10%): Abnormal renal function
Frequency not reported: Acute interstitial nephritis, cystitis, renal insufficiency, acute renal failure, nephrotic syndrome, renal calculi[Ref]


Frequency not reported: Arrhythmia, blood pressure changes, congestive heart failure, hypertension, hypotension, myocardial infarction, palpitations, tachycardia, syncope, vasculitis[Ref]

Nervous system

Common (1% to 10%): CNS inhibition, somnolence, sedation, dizziness, headache
Frequency not reported: Taste disturbance, coma, convulsions, drowsiness, paresthesia, tremors[Ref]


Common (1% to 10%): Pruritus, rash
Frequency not reported: Ecchymosis, purpura, alopecia, angioedema, urticaria, photosensitivity, pseudoporphyria, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, sweating, toxic epidermal necrolysis[Ref]


Common (1% to 10%): Anemia, bleeding time increased
Frequency not reported: Agranulocytosis, aplastic anemia, eosinophilia, hemolytic anemia, lymphadenopathy, pancytopenia, thrombocytopenia, leukopenia[Ref]


Frequency not reported: Hypersensitivity reactions[Ref]


Common (1% to 10%): Edema, tinnitus
Frequency not reported: Death, sepsis, fever, infection, asthenia, malaise, meningitis, vertigo, weakness, hearing decreased[Ref]


Common (1% to 10%): Depression, confusion, sleep disturbance, dream abnormalities
Frequency not reported: Anxiety, hallucinations, insomnia, nervousness[Ref]


Common (1% to 10%): Dysuria, urinary frequency
Frequency not reported: Hematuria, menstrual flow increased, oliguria, polyuria, proteinuria, menstrual flow decreased[Ref]


Frequency not reported: Asthma, dyspnea, pulmonary infections, pneumonia, sinusitis, upper respiratory tract infection, respiratory depression[Ref]


Frequency not reported: Serum sickness[Ref]


Frequency not reported: Appetite changes, hyperglycemia, weight changes[Ref]


Frequency not reported: Blurred vision, conjunctivitis[Ref]


1. "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL.

Not all side effects for Daypro may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.