Corgard Side Effects

Generic name: nadolol

Note: This document contains side effect information about nadolol. Some of the dosage forms listed on this page may not apply to the brand name Corgard.

Some side effects of Corgard may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to nadolol: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking nadolol (the active ingredient contained in Corgard) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• slow or uneven heartbeats;

• numbness or cold feeling;

• feeling like you might pass out;

• feeling short of breath, even with mild exertion;

• swelling or rapid weight gain;

• bronchospasm (wheezing, chest tightness, trouble breathing);

• hallucinations, behavior changes; or

• nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects of nadolol may include:

• dizziness, spinning sensation;

• tired feeling;

• mild nausea, diarrhea, constipation, upset stomach, bloating, gas; or

• tingly feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to nadolol: compounding powder, oral tablet

Cardiovascular

Rare cases of A-V heart block are reported.

Cardiovascular side effects are usually mild and transient and rarely require discontinuation of therapy. Bradycardia, hypotension, conduction disturbances, chest pain, and heart failure have each been reported in 1% to 3% of patients. Complaints of cold extremities have been reported in approximately 5% of patients. Edema has rarely been associated with the use of nadolol.

Nervous system

Nadolol is hydrophilic and is less likely to penetrate into the central nervous system compared to other beta-blockers. Depression and anxiety are reported in one patient while receiving nadolol (the active ingredient contained in Corgard) The symptoms started two days after an increase in his dosage and resolved within three days of discontinuing nadolol. Organic brain syndrome was diagnosed in two patients receiving nadolol should be considered as a possible cause of acute deterioration in mental or emotional status.

The most common nervous system side effect appears to be fatigue (up to 10% of patients). Headache or dizziness have been reported in 5% and 8% of patients, respectively.

Respiratory

At least one case of severe bronchospasm associated with nadolol (the active ingredient contained in Corgard) therapy is reported. This patient had a history of childhood asthma and exercise-induced bronchospasm requiring albuterol inhalations. After one dosage of nadolol the patient had a respiratory arrest and required mechanical ventilation for several days. If nadolol is necessary in a patient with a history of bronchospasm, it is recommended that therapy be initiated in a controlled environment with bronchodilators available.

Respiratory system side effects have been rare (1 in 1,000), but may be important in patients with reactive airways disease. The use of nadolol has been associated with precipitation of bronchospasm in patients with a history of asthma.

Gastrointestinal

Gastrointestinal problems, such as nausea, diarrhea, constipation, and general abdominal upset have each been reported in less than 1% of patients.

Psychiatric

Psychiatric side effects have been limited to anxiety-depression in approximately 4% of patients.

Renal

Renal insufficiency has not associated with nadolol (the active ingredient contained in Corgard) but one study of 10 elderly hypertensive patients has shown that the antihypertensive effect of nadolol was associated with a decrease in effective renal blood flow. The glomerular filtration rate in affected patients remained stable, however.

Hematologic

Hematologic side effects have included at least one reported case of nadolol-associated thrombocytopenia.

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