Clindamycin / tretinoin topical Side Effects

Not all side effects for clindamycin / tretinoin topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to clindamycin / tretinoin topical: topical application gel/jelly

In addition to its needed effects, some unwanted effects may be caused by clindamycin / tretinoin topical. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking clindamycin / tretinoin topical:

More common
  • Dryness and peeling of the skin
  • flushing or redness of the skin
  • itching
  • unusually warm skin
Less common
  • Burning or stinging at the site of application
  • changes in the color of the skin
  • fever
  • stomach cramps, tenderness, or pain
  • watery or bloody diarrhea

Some of the side effects that can occur with clindamycin / tretinoin topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Cough
  • dry skin
  • headaches
  • muscle aches
  • pain and tenderness around the eyes and cheekbones
  • shortness of breath or troubled breathing
  • sore throat
  • stuffy or runny nose
  • tightness of the chest or wheezing
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clindamycin / tretinoin topical: topical gel

General

The most commonly reported side effects were erythema, dryness, and itching.

Dermatologic

Very common (10% or more): Erythema, dryness
Common (1% to 10%): Sunburn, scaling, burning, itching
Uncommon (0.1% to 1%): Acne, dry skin, seborrhea, photosensitivity reaction, pruritus, rash, exfoliative rash, skin exfoliation
Rare (less than 0.1%): Dermatitis, herpes simplex, rash macular, skin bleeding, skin depigmentation, skin irritation

Local

Common (1% to 10%): Application site dryness, application site irritation, application site exfoliation, application site erythema, application site pruritus, application site dermatitis
Uncommon (0.1% to 1%): Application site reaction, application site burning
Rare (less than 0.1%): Application site swelling, application site erosion, application site discoloration, application site desquamation

Other

Rare (less than 0.1%): Feeling hot, pain

Endocrine

Rare (less than 0.1%): Hypothyroidism

Gastrointestinal

Rare (less than 0.1%): Gastroenteritis, nausea

Hypersensitivity

Rare (less than 0.1%): Hypersensitivity

Nervous system

Rare (less than 0.1%): Headache

Ocular

Rare (less than 0.1%): Eye irritation

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