Clindamycin / tretinoin topical Pregnancy and Breastfeeding Warnings

Clindamycin / tretinoin topical is also known as: Veltin, Ziana

Clindamycin / tretinoin topical Pregnancy Warnings

Animal studies have failed to reveal evidence of teratogenicity when high doses of clindamycin are given systemically. Oral tretinoin has been shown to be teratogenic and fetotoxic in high dose studies conducted in rats. Topical tretinoin was associated with fetal malformations and teratogenicity in some animal studies. However, there have been reports of possible teratogenicity related to topical tretinoin use during early pregnancy, including case reports of holoprosencephaly, ear malformation, limb reduction defects.

Clindamycin-tretinoin topical has been assigned to pregnancy category C by the FDA. Animal testing on clindamycin-tretinoin topical gel reported the drug to be in the no observed averse effect level (NOAEL). There are no controlled data in human pregnancy. Some experts suggest that topical tretinoin does not increase the risk of malformations, while others recommend avoiding its use during the first trimester or during the entire pregnancy. Topical clindamycin-tretinoin should only be given during pregnancy when benefits outweigh risks.

Clindamycin / tretinoin topical Breastfeeding Warnings

There are no data on the excretion of clindamycin into human milk following topical administration. Clindamycin is excreted following systemic administration. There are no data on the excretion of tretinoin topical into human milk. Because many drugs are excreted into human milk and because of the potential for serious adverse reactions to Clindamycin-tretinoin in nursing infants, a decision should be made to discontinue nursing or discontinue the drug.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.