Clindamycin / tretinoin topical Pregnancy and Breastfeeding Warnings

Clindamycin / tretinoin topical is also known as: Veltin, Ziana

Clindamycin / tretinoin topical Pregnancy Warnings

Animal studies have failed to reveal evidence of teratogenicity when high doses of clindamycin are given systemically. Oral tretinoin has been shown to be teratogenic and fetotoxic in high dose studies conducted in rats. Topical tretinoin was associated with fetal malformations and teratogenicity in some animal studies. However, there have been reports of possible teratogenicity related to topical tretinoin use during early pregnancy, including case reports of holoprosencephaly, ear malformation, limb reduction defects.

Clindamycin-tretinoin topical has been assigned to pregnancy category C by the FDA. Animal testing on clindamycin-tretinoin topical gel reported the drug to be in the no observed averse effect level (NOAEL). There are no controlled data in human pregnancy. Some experts suggest that topical tretinoin does not increase the risk of malformations, while others recommend avoiding its use during the first trimester or during the entire pregnancy. Topical clindamycin-tretinoin should only be given during pregnancy when benefits outweigh risks.

Clindamycin / tretinoin topical Breastfeeding Warnings

There are no data on the excretion of clindamycin into human milk following topical administration. Clindamycin is excreted following systemic administration. There are no data on the excretion of tretinoin topical into human milk. Because many drugs are excreted into human milk and because of the potential for serious adverse reactions to Clindamycin-tretinoin in nursing infants, a decision should be made to discontinue nursing or discontinue the drug.

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