Skip to main content

Chlorthalidone / Clonidine Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 15, 2023.

Applies to chlorthalidone / clonidine: oral tablet.

Other side effects

Some side effects of chlorthalidone / clonidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • constipation
  • dizziness
  • drowsiness
  • dryness of mouth
  • unusual tiredness or weakness

Less common

  • decreased sexual ability
  • diarrhea
  • dizziness or lightheadedness when getting up from a lying or sitting position
  • dry, itching, or burning eyes
  • increased sensitivity of skin to sunlight
  • loss of appetite
  • nausea or vomiting
  • nervousness
  • upset stomach

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:

Serious side effects

Along with its needed effects, chlorthalidone/clonidine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlorthalidone / clonidine:

Signs and symptoms of overdose

Check with your doctor as soon as possible if any of the following side effects occur while taking chlorthalidone / clonidine:

Signs and symptoms of too much potassium loss

Signs and symptoms of too much sodium loss

Less common

  • mental depression
  • swelling of feet and lower legs

Rare

  • black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • joint pain
  • lower back or side pain
  • paleness or cold feeling in fingertips and toes
  • pinpoint red spots on skin
  • skin rash or hives
  • stomach pain (severe) with nausea and vomiting
  • unusual bleeding or bruising
  • vivid dreams or nightmares
  • yellow eyes or skin

For healthcare professionals

Applies to chlorthalidone / clonidine: oral tablet.

General

The most frequent adverse reactions were dry mouth, drowsiness, dizziness, constipation, and sedation.[Ref]

Gastrointestinal

Chlorthalidone:

Clonidine:

Nervous system

Chlorthalidone:

Clonidine:

Other

Chlorthalidone:

Clonidine:

Cardiovascular

Chlorthalidone:

Clonidine:

Dermatologic

Chlorthalidone:

Clonidine:

Genitourinary

Chlorthalidone:

Clonidine:

Hematologic

Chlorthalidone:

Clonidine:

Hepatic

Chlorthalidone:

Clonidine:

Metabolic

Chlorthalidone:

Clonidine:

Musculoskeletal

Chlorthalidone:

Clonidine:

Ocular

Chlorthalidone:

Clonidine:

Psychiatric

Chlorthalidone:

Clonidine:

Renal

Clonidine:

References

1. (2022) "Product Information. Combipres (chlorthalidone-clonidine)." Apothecon Inc

Further information

Chlorthalidone/clonidine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.