Cefoxitin Side Effects
Some side effects of cefoxitin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to cefoxitin: intravenous powder for solution, intravenous solution
Along with its needed effects, cefoxitin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking cefoxitin:More common
- Changes in skin color
- swelling of the foot or leg
- decreased urine output
- muscle twitching
- rapid weight gain
- swelling of the face, ankles, or hands
- unusual tiredness or weakness
- Abdominal or stomach cramps or tenderness
- back, leg, or stomach pains
- bleeding and bruising
- bleeding gums
- blistering, peeling, or loosening of the skin
- bloody or cloudy urine
- bloody, black, or tarry stools
- chest pain
- clay-colored stools
- cloudy urine
- coughing up blood
- cracks in the skin
- dark urine
- decrease in urine output or decrease in urine-concentrating ability
- diarrhea, watery and severe, which may also be bloody
- difficult or labored breathing
- difficult or painful urination
- difficulty with breathing, chewing, swallowing, or talking
- double vision
- drooping eyelids
- fast heartbeat
- feeling of discomfort
- general body swelling
- greatly decreased frequency of urination or amount of urine
- high fever
- increased menstrual flow or vaginal bleeding
- increased thirst
- inflammation of the joints
- itching of the vagina or genital area
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- loss of heat from the body
- muscle aches
- muscle weakness
- pain during sexual intercourse
- pale skin
- prolonged bleeding from cuts
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red or black, tarry stools
- red or dark brown urine
- red skin lesions, often with a purple center
- red, irritated eyes
- red, swollen skin
- scaly skin
- severe tiredness
- shortness of breath
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- sudden decrease in the amount of urine
- swelling of the feet or lower legs
- swollen lymph glands
- swollen or painful glands
- thick, white vaginal discharge with no odor or with a mild odor
- tightness in the chest
- troubled breathing with exertion
- unexplained bleeding or bruising
- unpleasant breath odor
- unusual bleeding or bruising
- unusual weight loss
- vomiting of blood
- yellowing of the eyes or skin
Some side effects of cefoxitin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Red streaks on the skin
- swelling, tenderness, or pain at the injection site
- Hives or welts
- redness of the skin
For Healthcare Professionals
Applies to cefoxitin: injectable powder for injection, intravenous solution
Cefoxitin is generally well-tolerated.
Hypersensitivity reactions have included pruritus, rash, exfoliative dermatitis, toxic epidermal necrolysis, urticaria, flushing, dyspnea, angioedema, anaphylaxis, interstitial nephritis, eosinophilia, and fever. Cephalosporin class antibiotics have been associated with erythema multiforme, Stevens-Johnson syndrome, and serum sickness-like reactions.
There is a 10% to 20% chance of an allergic reaction to cefoxitin (or any cephalosporin) among patients who are allergic to a penicillin.
A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.
Gastrointestinal side effects have included nausea, vomiting, diarrhea, and pseudomembranous colitis. Cephalosporin class antibiotics have been associated with abdominal pain and colitis.
A 60-year-old man with bilateral staghorn renal calculi, Proteus mirabilis urinary tract infection, and acute renal failure developed non-bloody diarrhea and fever associated with leukocytosis and ileus within two days after beginning cefoxitin 1 gram intravenously once a day. Sigmoidoscopy and stool pathology revealed innumerable small white plaques and Clostridium difficile toxin. The cefoxitin was stopped, vancomycin retention enemas were given (due to ileus, oral vancomycin was not tried), and the patient recovered.
A study of 374 patients demonstrated that of 21 patients developing Clostridium difficile colitis, 17.9% had received cefoxitin.
Pseudomembranous colitis may occur during or after treatment.
Nervous system side effects have included somnolence, dizziness, and headache. Some cephalosporin-class antibiotics have been associated with seizures, especially in patients with renal dysfunction.
Renal side effects have included increased serum creatinine and blood urea nitrogen, and acute renal failure (rare). Cephalosporin class antibiotics have been associated with renal dysfunction, toxic nephropathy, reversible, dose-related acute tubular necrosis, and interstitial nephritis. Interstitial nephritis manifests as reversible fever, azotemia, pyuria, and eosinophiluria.
Local side effects have included thrombophlebitis with intravenous administration.
Cardiovascular side effects have included hypotension.
Musculoskeletal side effects have included exacerbation of myasthenia gravis.
Hematologic side effects have included eosinophilia, leukopenia, granulocytopenia, neutropenia, anemia, hemolytic anemia, thrombocytopenia, bone marrow depression, and positive direct Coombs' test. Cephalosporin class antibiotics have been associated with aplastic anemia, hemorrhage, prolonged prothrombin time, pancytopenia, and agranulocytosis.
Hepatic side effects have included transient elevations of SGOT, SGPT, LDH, and alkaline phosphatase, and jaundice. Cephalosporin class antibiotics have been associated with hepatic dysfunction, cholestasis, and elevated bilirubin.
Genitourinary side effects associated with cephalosporin class antibiotics have included vaginitis, vaginal candidiasis, and false positive tests for urine glucose.
Other side effects associated with cephalosporin class antibiotics have included superinfection.
Other side effects associated with higher doses of cefoxitin have included an increased incidence of SGOT elevations and eosinophilia in pediatric patients.
More cefoxitin resources
- cefoxitin Concise Consumer Information (Cerner Multum)
- cefoxitin MedFacts Consumer Leaflet (Wolters Kluwer)
- cefoxitin Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
- Cefoxitin Prescribing Information (FDA)
- Cefoxitin Sodium Monograph (AHFS DI)
- Mefoxin Prescribing Information (FDA)
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