Cefadroxil Side Effects

Not all side effects for cefadroxil may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cefadroxil: oral capsule, oral powder for suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by cefadroxil. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking cefadroxil:

Rare
  • Black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • chills
  • clay-colored stools
  • cough or hoarseness
  • dark-colored urine
  • diarrhea
  • difficulty with moving
  • feeling of discomfort
  • fever
  • fever with or without chills
  • flushing or redness of the skin
  • general feeling of tiredness or weakness
  • headache
  • inflammation of the joints
  • itching
  • joint or muscle pain
  • light-colored stools
  • lower back or side pain
  • muscle aches
  • muscle pain or stiffness
  • painful or difficult urination
  • pinpoint red spots on the skin
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain, continuing
  • swollen lymph glands
  • unusual bleeding or bruising
  • unusually warm skin
  • vomiting
  • yellow eyes or skin
Incidence not known
  • Abdominal or stomach cramps or tenderness
  • back, leg, or stomach pains
  • bloating
  • chest pain
  • coughing up blood
  • diarrhea, watery and severe, which may also be bloody
  • difficulty with breathing or swallowing
  • dizziness
  • fast heartbeat
  • general body swelling
  • high fever
  • hives
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • nausea
  • nosebleeds
  • pain
  • pale skin
  • paralysis
  • prolonged bleeding from cuts
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • shortness of breath
  • sudden decrease in the amount of urine
  • swollen or painful glands
  • tightness in the chest
  • unpleasant breath odor
  • unusual tiredness or weakness
  • unusual weight loss
  • vomiting of blood
  • wheezing

Some of the side effects that can occur with cefadroxil may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Rare
  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • stomach discomfort, upset, or pain
Incidence not known
  • Hives or welts
  • itching of the vagina or genital area
  • itching or pain of the genital area
  • pain during sexual intercourse
  • redness of the skin
  • thick, white vaginal discharge with no odor or with a mild odor

For Healthcare Professionals

Applies to cefadroxil: oral capsule, oral powder for reconstitution, oral tablet

Hypersensitivity

Up to 20% of patients with penicillin allergy may demonstrate allergic reactions to cefadroxil. One study reported only 12% of patients with a confirmed allergy to amoxicillin (same side-chain as cefadroxil) showed an allergy to cefadroxil.[Ref]

Hypersensitivity reactions have included urticaria, rash, erythema multiforme, Stevens-Johnson syndrome, serum sickness, angioedema, anaphylaxis, eosinophilia, and fever. Cephalosporin-class antibiotics have been associated with toxic epidermal necrolysis.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, general abdominal discomfort, and dyspepsia. Pseudomembranous colitis may occur during or after treatment.[Ref]

Nervous system

Nervous system side effects associated with some cephalosporin-class antibiotics have included seizures in renally impaired patients when the dosage was not reduced.[Ref]

Renal

Renal side effects associated with cephalosporin-class antibiotics have included renal dysfunction, toxic nephropathy, elevated BUN and creatinine, interstitial nephritis, and acute tubular necrosis.[Ref]

Hepatic

Hepatic side effects have included cholestasis, idiosyncratic hepatic failure, and elevations in serum transaminases. Cephalosporin-class antibiotics have been associated with elevated LDH, alkaline phosphatase, and bilirubin.[Ref]

Genitourinary

Genitourinary side effects have included genital pruritus, genital moniliasis, and vaginitis,[Ref]

Hematologic

Hematologic side effects have included moderate transient neutropenia, agranulocytosis, and thrombocytopenia. Cephalosporin-class antibiotics have been associated with aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs' test, eosinophilia, and pancytopenia.[Ref]

Other

Cephalosporin-class antibiotics have been associated with superinfection.[Ref]

Musculoskeletal

Musculoskeletal side effects have included arthralgia.[Ref]

References

1. Filipe P, Almeida RSLS, Rodrigo FG "Occupational allergic contact dermatitis from cephalosporins." Contact Dermatitis 34 (1996): 226

2. Sastre J, Quijano LD, Novalbos A, Hernandez G, Cuesta J, de las Heras M, Lluch M, Fernandez M "Clinical cross-reactivity between amoxicillin and cephadroxil in patients allergic to amoxicillin and with good tolerance o penicillin." Allergy 51 (1996): 383-86

3. "Product Information. Duricef (cefadroxil)." Bristol-Myers Squibb, Princeton, NJ.

4. Gooch WM, Kaminester L, Cole GW, et al "Clinical comparison of cefuroxime axetil, cephalexin and cefadroxil in the treatment of patients with primary infections of the skin or skin structures." Dermatologica 183 (1991): 36-43

5. Neldner KH "Double-blind randomized study of oral temafloxacin and cefadroxil in patients with mild to moderately severe bacterial skin infections." Am J Med 91 (1991): s111-4

6. Haskell RJ, Fujita NK, Stevenson JA, Border WA "Cefoxitin-induced interstitial nephritis." Arch Intern Med 141 (1981): 1557

7. Toll LL, Lee M, Sharifi R "Cefoxitin-induced interstitial nephritis." South Med J 80 (1987): 274-5

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