Cefadroxil Side Effects

Brand Names: Duricef

Please note - some side effects for Cefadroxil may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Cefadroxil - for the Consumer

Cefadroxil

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Cefadroxil:

Diarrhea; nausea; stomach upset; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; dark urine; decreased urination; fever, chills, or sore throat; joint pain; red, swollen, or blistered skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; unusual tiredness or weakness; vaginal itching, odor, or discharge; yellowing of the skin or eyes.

Cefadroxil Suspension

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Cefadroxil Suspension:

Diarrhea; nausea; stomach upset; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; dark urine; decreased urination; fever, chills, or sore throat; joint pain; red, swollen, or blistered skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; unusual tiredness or weakness; vaginal itching, odor, or discharge; yellowing of the skin or eyes.

Cefadroxil Side Effects - for the Professional

Cefadroxil

Gastrointestinal

Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. Dyspepsia, nausea and vomiting have been reported rarely. Diarrhea has also occurred.

Hypersensitivity

Allergies (in the form of rash, urticaria, angioedema, and pruritus) have been observed. These reactions usually subsided upon discontinuation of the drug. Anaphylaxis has also been reported.

Other

Other reactions have included hepatic dysfunction including cholestasis and elevations in serum transaminase, genital pruritus, genital moniliasis, vaginitis, moderate transient neutropenia, fever. Agranulocytosis, thrombocytopenia, idiosyncratic hepatic failure, erythema multiforme, Stevens-Johnson syndrome, serum sickness, and arthralgia have been rarely reported.

In addition to the adverse reactions listed above which have been observed in patients treated with Cefadroxil, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:

Toxic epidermal necrolysis, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs’ test, increased BUN, increased creatinine, elevated alkaline phosphatase, elevated aspartate aminotransferase (AST), elevated alanine aminotransferase (ALT), elevated bilirubin, elevated LDH, eosinophilia, pancytopenia, neutropenia.

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment, when the dosage was not reduced. If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

Side Effects by Body System

Hypersensitivity

Up to 20% of patients with penicillin allergy may demonstrate allergic reactions to cefadroxil. One study reported only 12% of patients with a confirmed allergy to amoxicillin (same side-chain as cefadroxil) showed an allergy to cefadroxil.

Hypersensitivity reactions have included urticaria, rash, erythema multiforme, Stevens-Johnson syndrome, serum sickness, angioedema, anaphylaxis, eosinophilia, and fever. Cephalosporin-class antibiotics have been associated with toxic epidermal necrolysis.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, general abdominal discomfort, and dyspepsia. Pseudomembranous colitis may occur during or after treatment.

Nervous system

Nervous system side effects associated with some cephalosporin-class antibiotics have included seizures in renally impaired patients when the dosage was not reduced.

Renal

Renal side effects associated with cephalosporin-class antibiotics have included renal dysfunction, toxic nephropathy, elevated BUN and creatinine, interstitial nephritis, and acute tubular necrosis.

Hepatic

Hepatic side effects have included cholestasis, idiosyncratic hepatic failure, and elevations in serum transaminases. Cephalosporin-class antibiotics have been associated with elevated LDH, alkaline phosphatase, and bilirubin.

Genitourinary

Genitourinary side effects have included genital pruritus, genital moniliasis, and vaginitis,

Hematologic

Hematologic side effects have included moderate transient neutropenia, agranulocytosis, and thrombocytopenia. Cephalosporin-class antibiotics have been associated with aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs' test, eosinophilia, and pancytopenia.

Other

Cephalosporin-class antibiotics have been associated with superinfection.

Musculoskeletal

Musculoskeletal side effects have included arthralgia.

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