Bactroban Nasal Side Effects

Generic Name: mupirocin topical

Note: This page contains information about the side effects of mupirocin topical. Some of the dosage forms included on this document may not apply to the brand name Bactroban Nasal.

Not all side effects for Bactroban Nasal may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to mupirocin topical: topical cream, topical ointment

Other dosage forms:

Along with its needed effects, mupirocin topical (the active ingredient contained in Bactroban Nasal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects of mupirocin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Dry skin
  • skin burning, itching, pain, rash, redness, stinging, or swelling
  • headache
  • nausea
  • Abdominal pain
  • dizziness
  • secondary wound infection
  • sores on mouth and on lips

For Healthcare Professionals

Applies to mupirocin topical: compounding powder, nasal ointment, topical cream, topical kit, topical ointment


Local adverse effects may be associated with mupirocin application. Mupirocin ointment or cream may commonly cause itching, pain, stinging, and burning. Local effects from the nasal formulation have included epistaxis, rhinitis, taste perversion, pharyngitis, burning, and cough.

Mupirocin ointment in a polyethylene glycol base has previously (prior to the release of a nasal formulation) been used intranasally. Common side effects associated with such use, which may be related to the polyethylene glycol, include nasal congestion, dryness, burning or irritation and unpleasant taste.


Gastrointestinal side effects have included nausea (1.1%), abdominal pain (<1%), and diarrhea (<1%). Dry mouth has been reported with mupirocin nasal (<1%).


Hypersensitivity reactions have infrequently included allergic contact dermatitis.

Nervous system

Nervous system side effects associated with intranasal mupirocin have included headache (9%). Dizziness has been reported with mupirocin ointment (<1%).


Ocular side effects associated with mupirocin nasal ointment have included blepharitis (<1%).


Dermatologic side effects associated with mupirocin ointment or cream have included pain and bleeding secondary to eczema, cellulitis, dermatitis, increased exudate, secondary wound infection, hives, and rash.

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