Actos Side Effects

Generic Name: pioglitazone

Note: This page contains information about the side effects of pioglitazone. Some of the dosage forms included on this document may not apply to the brand name Actos.

Not all side effects for Actos may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to pioglitazone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by pioglitazone (the active ingredient contained in Actos). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking pioglitazone:

More common
  • Chest pain
  • decreased urine output
  • dilated neck veins
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • problems with teeth
  • shortness of breath
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • trouble with breathing
  • weight gain
  • wheezing
Less common
  • Pain or swelling in the arms or legs without an injury
  • pale skin
  • swelling
  • trouble with breathing when active
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Incidence not known
  • Dark urine
  • loss of appetite
  • nausea or vomiting
  • stomach pain
  • unexplained, rapid weight gain
  • yellow eyes or skin

Some of the side effects that can occur with pioglitazone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Blurred vision or other changes in vision
  • cough
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • loss of consciousness
  • muscle pain or soreness
  • problems with your teeth
  • runny or stuffy nose
  • sore throat
  • stomachache
  • sweating
  • unexplained weight loss

For Healthcare Professionals

Applies to pioglitazone: oral tablet

Cardiovascular

Common (1% to 10%): Congestive heart failure (including nonfatal and fatal cases), cardiac failure, chest pain[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity and allergic reactions[Ref]

Metabolic

Very common (10% or more): Hypoglycemia (up to 27.3%), increased weight (up to 26.2%)[Ref]

General

The most commonly reported side effects were hypoglycemia, increased weight, edema, and upper respiratory tract infection.[Ref]

Hematologic

Frequency not reported: Small reduction in mean hemoglobin and hematocrit[Ref]

Ocular

Common (1% to 10%): Visual disturbance, abnormal vision
Frequency not reported: Macular edema[Ref]

Hepatic

Uncommon (0.1% to 1%): Increased alanine aminotransferase
Frequency not reported: Decreased mean values of bilirubin, AST, alkaline phosphatase, and GGT
Postmarketing reports: Hepatocellular dysfunction[Ref]

Other

Very common (10% or more): Edema (up to 26.7%)
Common (1% to 10%): Fatigue, accidental injury, peripheral edema, asthenia, malaise[Ref]

Gastrointestinal

Common (1% to 10%): Tooth disorder, tooth abscess, gastroenteritis, diarrhea, upper abdominal pain[Ref]

Genitourinary

Uncommon (0.1% to 1%): Bladder cancer, urinary tract infection[Ref]

Musculoskeletal

Common (1% to 10%): Fractures, myalgia, pain in extremity, back pain, cramped legs, arthralgia[Ref]

Nervous system

Common (1% to 10%): Headache, Hypoesthesia[Ref]

Psychiatric

Uncommon (0.1% to 1%): Insomnia[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (up to 13.2%)
Common (1% to 10%): Sinusitis, pharyngitis, bronchitis, influenza[Ref]

Oncologic

Uncommon (0.1% to 1%): Bladder cancer[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Actos (pioglitazone)" Takeda Pharmaceuticals America, Lincolnshire, IL.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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