Accupril Side Effects

Generic Name: quinapril

Note: This page contains information about the side effects of quinapril. Some of the dosage forms included on this document may not apply to the brand name Accupril.

Not all side effects for Accupril may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to quinapril: oral tablet

In addition to its needed effects, some unwanted effects may be caused by quinapril (the active ingredient contained in Accupril). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking quinapril:

Less common
  • Abdominal or stomach pain
  • blurred vision
  • chest pain
  • confusion
  • diarrhea
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nausea
  • sweating
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting

Some of the side effects that can occur with quinapril may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Headache
Less common
  • Back pain
  • coughing
  • difficulty with moving
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • rash
  • swollen joints

For Healthcare Professionals

Applies to quinapril: oral tablet

General

The most commonly reported side effects were dizziness, increased serum creatinine, increased blood urea nitrogen, cough, dyspnea, nausea, vomiting, and diarrhea.[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Chest pain, hypotension, palpitations, vasodilation, tachycardia, heart failure, myocardial infarction, hypertensive crisis, angina pectoris, orthostatic hypotension, cardiac rhythm disturbances, cardiogenic shock[Ref]

Renal

Common (1% to 10%): Increased serum creatinine, increased blood urea nitrogen
Uncommon (0.1% to 1%): Urinary tract infection, acute renal failure/dysfunction, worsening renal failure, proteinuria
Frequency not reported: Increases in blood urea nitrogen and serum creatinine[Ref]

Metabolic

Uncommon (0.1% to 1%): Hyperkalemia[Ref]

Hematologic

Uncommon (0.1% to 1%): Hemolytic anemia, agranulocytosis, thrombocytopenia
Frequency not reported: Neutropenia, decreased hemoglobin, decreased hematocrit[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Angioedema of the head, neck, face, extremities, lips, tongue, glottis and/or larynx, intestines; anaphylactoid reactions[Ref]

Hepatic

Uncommon (0.1% to 1%): Abnormal liver function tests, hepatitis
Rare (less than 0.1%): Hepatic failure (characterized by cholestatic jaundice with progression to fulminant hepatic necrosis and sometimes death)
Frequency not reported: Cholestatic icterus[Ref]

Nervous system

Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Headache, cerebrovascular accident/cerebral hemorrhage, somnolence, vertigo, syncope, nervousness, paresthesia, transient ischemic attacks, tinnitus
Rare (less than 0.1%): Balance disorder[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, diarrhea, dyspepsia, abdominal pain
Uncommon (0.1% to 1%): Flatulence, dry mouth or throat, constipation, gastrointestinal hemorrhage, pancreatitis
Rare (less than 0.1%): Glossitis
Very rare (less than 0.01%): Ileus[Ref]

Respiratory

Common (1% to 10%): Cough, pharyngitis, dyspnea, rhinitis
Uncommon (0.1% to 1%): Eosinophilic pneumonitis, sinusitis, upper respiratory tract infection, bronchitis
Frequency not reported: Bronchospasm[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Myalgia, back pain, arthralgia

Genitourinary

Uncommon (0.1% to 1%): Impotence[Ref]

Psychiatric

Uncommon (0.1% to 1%): Depression, insomnia, confusion[Ref]

Other

Common (1% to 10%): Fatigue, asthenia
Uncommon (0.1% to 1%): Fever, malaise, generalized/peripheral edema[Ref]

Immunologic

Uncommon (0.1% to 1%): Viral infection[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, alopecia, increased sweating, pemphigus, pruritus, exfoliative dermatitis, photosensitivity reaction, dermatopolymyositis
Rare (less than 0.1%): Urticaria, erythema multiforme, pemphigus
Very rare (less than 0.01%): Psoriasis-like efflorescence
Frequency not reported: Stevens Johnson syndrome, epidermal necrolysis[Ref]

Ocular

Uncommon (0.1% to 1): Amblyopia
Very rare (less than 0.01%): Blurred vision[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Accupril (quinapril)." Parke-Davis, Morris Plains, NJ.

3. Cerner Multum, Inc. "Australian Product Information." O 0

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