Quinapril use while Breastfeeding

Drugs containing Quinapril: Accupril, Accuretic, Quinaretic

Quinapril Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because of the low levels of quinapril in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

Drug Levels

Quinapril is an inactive drug that is metabolized to the active metabolite quinaprilat. Quinaprilat is poorly absorbed orally.

Maternal Levels. Six women who had been breastfeeding their infants for at least 2 weeks and were 4 to 9 months postpartum were given a single oral dose of 20 mg of quinapril. Quinapril milk levels were detectable at 4 hours after the dose, but undetectable (<5 mcg/L) in all samples by 6 hours after the dose. Quinalaprilat milk levels were undetectable (<5 mcg/L) at all time points. The authors estimated that a breastfed infant would receive about 1.6% of the maternal weight-adjusted dosage of quinapril.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Benazepril, Captopril, Enalapril

References

1. Begg EJ, Robson RA, Gardiner SJ et al. Quinapril and its metabolite quinaprilat in human milk. J Clin Pharmacol. 2001;51:478-81. PMID: 11422007

Quinapril Identification

Substance Name

Quinapril

CAS Registry Number

85441-61-8

Drug Class

  • Antihypertensive Agents
  • Angiotensin-Converting Enzyme Inhibitors

Administrative Information

LactMed Record Number

234

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

Hide
(web3)