A / T / S Side Effects

Generic Name: erythromycin topical

Note: This page contains information about the side effects of erythromycin topical. Some of the dosage forms included on this document may not apply to the brand name A / T / S.

Not all side effects for A / T / S may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to erythromycin topical: topical gel, topical ointment, topical solution, topical swab

Get emergency medical help if you have any of these signs of an allergic reaction while taking erythromycin topical (the active ingredient contained in A / T / S) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using erythromycin topical and call your doctor at once if you have any of these serious side effects:

  • severe burning, stinging, or redness;

  • oozing or other signs of skin infection;

  • worsening of your skin condition; or

  • diarrhea that is watery or bloody.

Less serious side effects of erythromycin topical may include:

  • mild skin irritation or tenderness;

  • dry or oily skin;

  • itching;

  • peeling; or

  • mild eye irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to erythromycin topical: topical gel, topical ointment, topical solution, topical swab


Local side effects are the most commonly reported adverse effects of topical erythromycin, and have included dryness, burning, tenderness, pruritus, desquamation, erythema, and oiliness. A single case of generalized urticarial reaction has been reported.


Ocular side effects have included eye irritation.

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