Trimethobenzamide Hydrochloride

Pronunciation: try-meth-oh-BEN-zuh-mide HIGH-droe-KLOR-ide
Class: Anticholinergic

Trade Names

Tigan
- Capsules 300 mg
- Injection 100 mg/mL

Pharmacology

Believed to directly affect medullary chemoreceptor trigger zone to inhibit nausea.

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Pharmacokinetics

Absorption

Following IM administration, T max is 30 min. After PO administration T max is 45 min. 300 mg oral capsules are equivalent to 200 mg IM. The bioavailability of the capsule formulation compared with the solution is 100%.

Elimination

Trimethobenzamide t ½ is 7 to 9 h.

Indications and Usage

Prevention and treatment of nausea and vomiting.

Contraindications

Hypersensitivity to benzocaine or other local anesthetics. Suppositories contraindicated in newborns or premature infants; parenteral use contraindicated in children.

Dosage and Administration

Adults

PO 250 mg 3 to 4 times daily. PR 200 mg 3 to 4 times daily. IM 200 mg 3 to 4 times daily.

Children 14 to 41 kg

PO 100 to 200 mg 3 to 4 times daily. PR 100 to 200 mg 3 to 4 times daily.

Children under 14 kg

PR 100 mg 3 to 4 times daily.

General Advice

  • Do not use oral route with vomiting.
  • Use Z-track technique for IM administration.

Storage/Stability

Avoid exposure to light; store at room temperature. Avoid freezing injectable.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Hypotension (after injection).

CNS

Mood depression; disorientation; headache; drowsiness; opisthotonos; dizziness; seizures; coma; Parkinson-like symptoms.

EENT

Blurred vision.

GI

Diarrhea.

Hematologic

Blood dyscrasias.

Hepatic

Jaundice.

Miscellaneous

Local pain, burning, stinging, redness and swelling (after injection); hypersensitivity reactions; muscle cramps.

Precautions

Pregnancy

Safety not established.

Lactation

Undetermined.

Hypersensitivity

Has been reported; discontinue use of drug at first signs of sensitivity.

Patient Information

  • Instruct patient that when used for motion sickness, medication should be taken 30 min before exposure to motion.
  • Advise patient to report these symptoms to health care provider: dizziness, yellowing of skin or eyes, muscle cramps, abnormal movements.
  • Instruct patient to avoid intake of alcoholic beverages or other CNS depressants.
  • Advise patient that drug may cause drowsiness or dizziness and to use caution while driving or performing tasks requiring mental alertness.

Copyright © 2009 Wolters Kluwer Health.

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