Trimethobenzamide Side Effects

Brand Names: Tigan

Please note - some side effects for Trimethobenzamide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Trimethobenzamide - for the Consumer

Trimethobenzamide

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Trimethobenzamide:

Blurred vision; depression; diarrhea; disorientation; dizziness; drowsiness; headache; muscle cramps.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); convulsions; fever; loss of balance; seizures; shuffling walk; sore throat; uncontrolled movements of the arms or legs; yellowing of the skin or eyes.

Trimethobenzamide Solution

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Trimethobenzamide Solution:

Blurred vision; depression; diarrhea; disorientation; dizziness; drowsiness; headache; muscle cramps; pain, redness, or swelling at the injection site.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); convulsions; fever; loss of balance; seizures; shuffling walk; sore throat; uncontrolled movements of the arms or legs; yellowing of the skin or eyes.

Trimethobenzamide/Benzocaine Suppositories

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Trimethobenzamide/Benzocaine Suppositories:

Dizziness; drowsiness; rectal irritation.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); loss of balance; seizures; shuffling walk; uncontrolled movements of the arms or legs; yellowing of the skin or eyes.

Trimethobenzamide Side Effects - for the Professional

Trimethobenzamide

There have been reports of hypersensitivity reactions and Parkinson-like symptoms. There have been instances of hypotension reported following parenteral administration to surgical patients. There have been reports of blood dyscrasias, blurring of vision, coma, convulsions, depression of mood, diarrhea, disorientation, dizziness, drowsiness, headache, jaundice, muscle cramps and opisthotonos. If these occur, the administration of the drug should be discontinued. Allergic-type skin reactions have been observed; therefore, the drug should be discontinued at the first sign of sensitization. While these symptoms will usually disappear spontaneously, symptomatic treatment may be indicated in some cases.

Side Effects by Body System

Nervous system

Nervous system adverse effects have included dizziness, drowsiness, headache, disorientation, coma, convulsions, depression of mood, opisthotonus, Parkinson's-like symptoms, trismus, and extrapyramidal symptoms.

Extrapyramidal reactions to trimethobenzamide have been reported in some patients, the youngest of whom was 2 weeks old. This patient received approximately 300 mg rectally, although the drug is not recommended for newborn infants.

Hypersensitivity

Hypersensitivity reactions have included allergic-type skin reactions.

Cardiovascular

Cardiovascular side effects have been reported rarely. Hypotension has been occasionally associated with intramuscular administration in surgical patients.

Psychiatric

Psychiatric side effects have included depression.

Gastrointestinal

Gastrointestinal adverse effects include diarrhea.

Hepatic

An isolated case report described a 50-year-old white female receiving trimethobenzamide capsules during a study protocol for use as a prophylactic antiemetic. After two days of administration, the patient had become jaundiced and her urine was dark. She felt tired, anorexic and nauseated with mild epigastric pain. A liver scan four days after the episode indicated hepatocellular dysfunction. She denied any other factors which may have contributed to the episode.

Hepatic side effects have included reports of jaundice and hepatotoxicity.

Musculoskeletal

Muscle cramps have occurred in some patients.

Hematologic

Hematologic side effects have rarely included blood dyscrasias.

Ocular

Ocular side effects have included reports of blurring of vision.

Dermatologic

Dermatologic side effects reported following intramuscular injection have included pain, stinging, burning, redness and swelling at the site of injection.

The manufacturer recommends giving trimethobenzamide by deep injection into the upper outer quadrant of the gluteal region, and avoiding the escape of the injectable solution along the route, in order to reduce the incidence of side effects at the injection site.

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