Desloratadine
Pronouncation: (dess-lore-AT-ah-deen)Class: Peripherally selective piperidine
Trade Names:
Clarinex
- Tablets 5 mg
Trade Names:
Clarinex RediTabs
- Tablets, rapidly disintegrating 5 mg
Pharmacology
Feedback for Desloratadine
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Long-acting histamine antagonist with selective H 1 -receptor histamine antagonist activity.
Pharmacokinetics
Absorption
T max approximately 3 h. C max approximately 4 ng/mL. AUC approximately 56.9 ng•h/mL.
Distribution
82% to 87% protein bound.
Metabolism
Metabolized to 3-hydroxydesloratadine (active).
Elimination
The t ½ is 27 h. Approximately 87% excreted in urine and feces.
Onset
1 h.
Duration
24 h.
Special Populations
Renal Function ImpairmentAUC and C max are increased. Dosage adjustment is recommended.
Hepatic Function ImpairmentAUC and t ½ are increased. Dosage adjustment is recommended.
ElderlyC max and AUC are 20% greater. The t ½ is 33.7 h.
Indications and Usage
Relief of nasal and nonnasal symptoms of seasonal and perennial allergic rhinitis; in chronic idiopathic urticaria for relief of symptoms of pruritus and reduction in number and size of hives.
Contraindications
Hypersensitivity to any components of the product or to loratadine.
Dosage and Administration
Adults and Children 12 yr of age and olderPO 5 mg once daily.
Renal/Hepatic impairmentPO 5 mg every other day.
Storage/Stability
Store tablets and orally disintegrating tablets at controlled room temperature (59° to 86°F). Do not remove orally disintegrating tablet from blister until just prior to administration.
Drug Interactions
None well documented.
Laboratory Test Interactions
May prevent or diminish otherwise positive reactions to skin tests.
Adverse Reactions
Cardiovascular
Tachycardia, palpitations (postmarketing).
CNS
Headache (14%); fatigue (5%); dizziness (4%); somnolence (2%).
EENT
Pharyngitis (4%); dry mouth (3%).
GI
Nausea (5%); dyspepsia (3%).
Genitourinary
Dysmenorrhea (2%).
Miscellaneous
Myalgia (3%); hypersensitivity (including rash, pruritus, urticaria, edema, dyspnea, anaphylaxis [postmarketing]).
Precautions
MonitorAssess patient for allergy symptoms (eg, rhinitis, nasal congestion, sneezing, itching, watery eyes, hives) before starting therapy and periodically throughout therapy. Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy. |
Pregnancy
Category C .
Lactation
Excreted in breast milk.
Children
Safety and efficacy not established in children younger than 12 yr of age.
Elderly
Select dose with caution, reflecting greater frequency of decreased hepatic, renal, or cardiac function and comorbidity.
Renal Function
Dosage adjustment is recommended.
Hepatic Function
Dosage adjustment is recommended.
Overdosage
Symptoms
Increased heart rate and corrected QT interval.
Patient Information
- Advise patient to take dose daily as prescribed and not to stop taking or change the dose unless advised by health care provider.
- Ensure patient understands how to store and take the orally disintegrating tablet.
- Advise patient to take without regard to meals but to take with food if stomach upset occurs.
- Advise patient that if allergy symptoms are not controlled, not to increase the dose of medication or frequency of use but to inform health care provider. Inform patient that larger or more frequent dosing does not increase effectiveness and may cause drowsiness.
- Caution patient to avoid alcohol and other CNS depressants (eg, sedatives) while using this medication.
- Caution patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness until tolerance is determined.
- Advise patient to take frequent sips of water, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
- If patient is to have allergy skin testing, advise not to take the medication for at least 4 days before the skin testing.
- Instruct patient to stop taking drug and report persistent dizziness or excessive drowsiness to health care provider.
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More Desloratadine resources:
Desloratadine - Includes detailed dosage instructions.
Desloratadine Drug Interactions
