Desloratadine Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Allergic Rhinitis

Initial dose: 5 mg orally once a day
Maintenance dose: 5 mg orally once a day

Usual Adult Dose for Urticaria

Initial dose: 5 mg orally once a day
Maintenance dose: 5 mg orally once a day

Usual Geriatric Dose for Allergic Rhinitis

Initial dose: 5 mg orally once a day.
Maintenance dose: 5 mg orally once a day.

Usual Geriatric Dose for Urticaria

Initial dose: 5 mg orally once a day.
Maintenance dose: 5 mg orally once a day.

Usual Pediatric Dose for Allergic Rhinitis

>=6m <12m: 1 mg orally once a day
>=1y <6y: 1.25 mg orally once a day
>=6y <11y: 2.5 mg orally once a day
>=12 years of age: 5 mg orally once a day

Usual Pediatric Dose for Urticaria

>=6m <12m: 1 mg orally once a day
>=1y <6y: 1.25 mg orally once a day
>=6y <11y: 2.5 mg orally once a day
>=12 years of age: 5 mg orally once a day

Renal Dose Adjustments

Initial dose: 5 mg orally once every other day.
Maintenance dose: 5 mg orally every other day.

Liver Dose Adjustments

Initial dose: 5 mg orally once every other day.
Maintenance dose: 5 mg orally every other day.

Precautions

During the marketing of desloratadine, the following spontaneous adverse events have been reported: tachycardia, elevated liver enzymes including bilirubin and rarely hypersensitivity reactions (such as rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis).

An increase in the incidence of somnolence has been reported in clinical trials (n=1838) at doses of 10 mg/day and 20 mg/day (5.2% and 7.6%, respectively), compared to placebo (2.3%).

A small sector of the general population (not prospectively identified) is unable to form 3-hydroxydesloratadine, resulting in up to 6 fold increase in AUC and half-life of over 50 hours. In pharmacokinetic studies (n=276). approximately 20% of blacks were slow metabolizers.

Dialysis

Desloratadine and its main active metabolite, 3-hydroxydesloratadine, are not removed by hemodialysis.

There are no data on the safe use of desloratadine in patients undergoing peritoneal dialysis.

Other Comments

Disintegrating tablet must be used immediately after opening the blister.

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