Generic Name: Fanapt (EYE loe PER i done)
Brand Names: Fanapt

What is Fanapt?

Fanapt (iloperidone) is an antipsychotic medication. It works by changing the effects of chemicals in the brain.

Fanapt is used to treat schizophrenia.

Fanapt may also be used for purposes not listed in this medication guide.

Important information

Fanapt is not for use in psychotic conditions related to dementia. Fanapt may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Before you take Fanapt, tell your doctor about all your medical conditions.

While you are taking Fanapt, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Fanapt.

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Fanapt may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid drinking alcohol. It can increase some of the side effects of Fanapt. Stop using this medicine and call your doctor at once if you have very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, restless muscle movements in your face or neck, tremor (uncontrolled shaking), trouble swallowing, or feeling like you might pass out.

If you have stopped taking Fanapt for any reason, talk with your doctor before you start taking it again. You may need to restart the medication at a lower dose.

Before taking this medicine

Fanapt is not for use in psychotic conditions related to dementia. It may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use Fanapt if you are allergic to iloperidone.

To make sure you can safely take Fanapt, tell your doctor if you have any of these other conditions:

  • kidney or liver disease;

  • a personal or family history of Long QT syndrome;

  • seizures or epilepsy;

  • heart disease, heart rhythm problems;

  • high blood pressure, high cholesterol;

  • a history of low white blood cell (WBC) counts;

  • a history of heart attack or stroke;

  • an electrolyte imbalance, such as low potassium or magnesium levels in your blood;

  • a history of breast cancer;

  • diabetes (Fanapt may raise your blood sugar);

  • trouble swallowing; or

  • a history of suicidal thoughts.

FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Fanapt, do not stop taking it without your doctor's advice. Do not start or stop taking Fanapt during pregnancy without your doctor's advice. The benefit of controlling your schizophrenia may outweigh any risks posed by taking Fanapt. It is not known whether iloperidone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking Fanapt. Older adults may be more likely to have side effects from this medicine.

See also: Pregnancy and breastfeeding warnings (in more detail)

How should I take Fanapt?

Take Fanapt exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Fanapt can be taken with or without food.

Your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.

Fanapt may cause you to have high blood sugar (hyperglycemia). Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking Fanapt.

If you have stopped taking Fanapt for any reason, talk with your doctor before you start taking it again. You may need to restart the medication at a lower dose.

Store at room temperature away from moisture, light, and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, fast heart rate, and feeling light-headed.

What should I avoid?

While you are taking Fanapt, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Fanapt. This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can increase certain side effects of Fanapt.

Fanapt side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Fanapt: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking this medication and call your doctor at once if you have a serious side effect such as:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;

  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;

  • high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);

  • thoughts about suicide or hurting yourself;

  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  • seizure (convulsions);

  • urinating less than usual or not at all;

  • trouble swallowing; or

  • penis erection that is painful or lasts 4 hours or longer.

Less serious Fanapt side effects may include:

  • dizziness, drowsiness, tired feeling;

  • dry mouth, stuffy nose;

  • breast swelling or discharge;

  • weight gain; or

  • changes in menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Fanapt?

Before using Fanapt, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Fanapt.

Tell your doctor about all other medicines you use, especially:

  • arsenic trioxide (Trisenox);

  • tacrolimus (Prograf);

  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), or pentamidine (NebuPent, Pentam);

  • an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), or desipramine (Norpramin);

  • anti-malaria medications such as chloroquine (Aralen) or mefloquine (Lariam);

  • heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);

  • medicine to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron (Zofran);

  • other medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);

  • migraine headache medicine such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig); or

  • narcotic medication such as methadone (Methadose, Diskets, Dolophine).

This list is not complete and other drugs may interact with Fanapt. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Fanapt.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 8.01. Revision Date: 2012-2-21, 5:09:47 PM.

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