Fanapt

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Treatment & Uses
Side Effects
Treating Overdose
Safety Information
Before Using

Generic Name: iloperidone (EYE loe PER i done)
Brand Names: Fanapt

What is Fanapt?

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Fanapt (iloperidone) is an antipsychotic medication. It works by changing the effects of chemicals in the brain.

Fanapt is used to treat schizophrenia.

Fanapt may also be used for other purposes not listed in this medication guide.

Important information about Fanapt

Fanapt is not for use in psychotic conditions related to dementia. Fanapt may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Before using Fanapt, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Fanapt.

Fanapt can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of Fanapt. Stop using this medicine and call your doctor at once if you have very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, restless muscle movements in your face or neck, tremor (uncontrolled shaking), trouble swallowing, or feeling like you might pass out.

If you have stopped taking Fanapt for any reason, talk with your doctor before you start taking it again. You may need to restart the medication at a lower dose.

Before taking Fanapt

Fanapt is not for use in psychotic conditions related to dementia. Iloperidone may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use Fanapt if you are allergic to iloperidone.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take Fanapt, tell your doctor if you have:

kidney or liver disease;
a personal or family history of Long QT syndrome;
seizures or epilepsy;
heart disease, high blood pressure, heart rhythm problems;
history of low white blood cell (WBC) counts;
a history of heart attack or stroke;
an electrolyte imbalance, such as low potassium or magnesium levels in your blood;
a history of breast cancer;
diabetes (Fanapt may raise your blood sugar);
trouble swallowing; or
a history of suicidal thoughts.

FDA pregnancy category C. It is not known whether Fanapt is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether iloperidone passes into breast milk or if it could harm a nursing baby. Do not use Fanapt without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medicine.

How should I take Fanapt?

Take Fanapt exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Fanapt can be taken with or without food.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.

Fanapt may cause you to have high blood sugar (hyperglycemia). Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking Fanapt.

If you have stopped taking Fanapt for any reason, talk with your doctor before you start taking it again. You may need to restart the medication at a lower dose.

Store this medicine at room temperature away from moisture, light, and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical treatment if you think you have used too much of this medicine.

Overdose symptoms may include drowsiness, fast heart rate, and feeling light-headed.

What should I avoid while taking Fanapt?

While you are taking Fanapt, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Fanapt. This medicine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. It can increase some of the side effects of Fanapt.

Fanapt side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Fanapt: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking this medication and call your doctor at once if you have a serious side effect such as:

very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
tremor (uncontrolled shaking);
trouble swallowing;
seizure (convulsions);
urinating less than usual or not at all;
fever, chills, body aches, flu symptoms;
white patches or sores inside your mouth or in your lips;
feeling like you might pass out; or
penis erection that is painful or lasts 4 hours or longer.

Less serious Fanapt side effects may include:

dizziness, drowsiness, tired feeling;
dry mouth, stuffy nose, sore throat;
nausea, diarrhea, upset stomach;
joint pain;
breast swelling or discharge;
changes in menstrual periods;
blurred vision;
weight gain; or
mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Fanapt?

The following drugs can interact with Fanapt. Tell your doctor if you are using any of these:

arsenic trioxide (Trisenox);
droperidol (Inapsine);
an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), ketoconazole (Nizoral), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam), rifampin (Rifadin, Rimactane, Rifater);
an antidepressant such as amitriptylline (Elavil, Vanatrip), clomipramine (Anafranil), desipramine (Norpramin), fluoxetine (Prozac, Sarafem), or paroxetine (Paxil);
anti-malaria medications such as chloroquine (Arelan), mefloquine (Lariam), or halofantrine (Halfan);
heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quinidex, Quin-Release Quin-G), or sotalol (Betapace);
medicine to prevent or treat nausea and vomiting, such as dolasetron (Anzemet) or ondansetron (Zofran);
other medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);
migraine headache medicine such as sumatriptan (Imitrex) or zolmitriptan (Zomig); or
narcotic medication such as levomethadyl (Orlaam), or methadone (Dolophine, Methadose).

This list is not complete and there may be other drugs that can interact with Fanapt. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about Fanapt.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.