Eprosartan Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 600 mg once daily assuming adequate intravascular volume
Maintenance dose: total daily doses of 400 to 800 mg administered once or twice daily

Renal Dose Adjustments

Maximum daily dose should not exceed 600 mg.

Liver Dose Adjustments

Maximum daily dose should not exceed 600 mg.

Precautions

There are numerous warnings and contraindications to the use of this drug during pregnancy. Drugs, like eprosartan, that act directly on the RAA system can cause fetal and neonatal morbidity and death when administered during pregnancy. Several dozen cases have been reported in the world literature in patients who were taking ACE inhibitors. When pregnancy is detected or expected, eprosartan should be discontinued as soon as possible.

In some patients whose renal function is dependent upon the renin-angiotensin-aldosterone (RAA) system, such as patients with severe congestive heart failure, use of angiotensin II receptor inhibitors has been associated with oliguria and/or progressive azotemia and (rarely) with acute renal failure and/or death. In addition, use of angiotensin II receptor inhibitors can lead to increases in BUN and serum creatinine in patients with unilateral or bilateral renal artery stenosis.

Symptomatic hypotension may occur in patients with an activated renin-angiotensin system (i.e., volume or salt depletion). Either of these conditions should be corrected before initiating therapy, or therapy should be initiated under close medical supervision.

Safety and effectiveness in pediatric patients have not been determined.

Dialysis

Limited data is available on the hemodialysis clearance of eprosartan; however, little removal is expected based on the relatively high plasma protein binding of this drug.

Other Comments

If blood pressure is not controlled by eprosartan alone, a diuretic may be added.

Compared with Caucasian patients, Black patients have a reduced blood pressure response to monotherapy with angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers; however, the reduced response is largely eliminated if combination therapy that includes an adequate dose of a diuretic is instituted.

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