This dosage information may not include all the information needed to use Bendroflumethiazide/Nadolol safely and effectively. See additional information for Bendroflumethiazide/Nadolol.
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 1 tablet (5 mg/40 mg) orally once a day.
Maintenance dose: Up to 5 mg/80 mg orally once a day.
Renal Dose Adjustments
CrCl greater than 50 mL/min: dosage interval should be 24 hours
CrCl 31 to 50 mL/min: increase dosage interval to 24 to 36 hours
CrCl 10 to 30 mL/min: increase dosage interval to 24 to 48 hours
CrCl less than 10 mL/min: increase dosage interval to 40 to 60 hours
Liver Dose Adjustments
Data not available
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Nadolol is moderately dialyzable (20 to 50%) via hemodialysis. A supplemental dose or postdialysis dose is recommended. Supplemental dose is not necessary following peritoneal dialysis.
The bendroflumethiazide in combination with nadolol results in a 30 percent increase in the dose of bendroflumethiazide alone due to increased bioavailability.