Bendroflumethiazide / Nadolol Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 1 tablet (5 mg/40 mg) orally once a day.
Maintenance dose: Up to 5 mg/80 mg orally once a day.

Renal Dose Adjustments

CrCl greater than 50 mL/min: dosage interval should be 24 hours

CrCl 31 to 50 mL/min: increase dosage interval to 24 to 36 hours

CrCl 10 to 30 mL/min: increase dosage interval to 24 to 48 hours

CrCl less than 10 mL/min: increase dosage interval to 40 to 60 hours

Liver Dose Adjustments

Data not available

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Nadolol is moderately dialyzable (20 to 50%) via hemodialysis. A supplemental dose or postdialysis dose is recommended. Supplemental dose is not necessary following peritoneal dialysis.

Other Comments

The bendroflumethiazide in combination with nadolol results in a 30 percent increase in the dose of bendroflumethiazide alone due to increased bioavailability.

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