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Bendroflumethiazide / nadolol Pregnancy and Breastfeeding Warnings

Bendroflumethiazide / nadolol is also known as: Corzide, Corzide 40/5, Corzide 80/5

Bendroflumethiazide / nadolol Pregnancy Warnings

Bendroflumethiazide has been assigned to pregnancy category C by the FDA. Animal reproduction studies have not been performed. There are no controlled data in human pregnancy. Some retrospective reviews have shown an increased risk of malformations associated with thiazide diuretics. Nadolol has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of embryo- and fetotoxicity in rabbits, but not in rats or hamsters, after dosages 5 to 10 times the maximum recommended human dosage (on a mg per kg basis). There are no controlled data in human pregnancy. Bendroflumethiazide-nadolol should only be given during pregnancy when there are no alternatives and benefits outweigh risk.

Bendroflumethiazide / nadolol Breastfeeding Warnings

Bendroflumethiazide and nadolol are excreted into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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