Atenolol / Chlorthalidone Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 1 tablet (atenolol/chlorthalidone 50 mg-25 mg) orally once a day.
Maintenance dose: May increase to 1 tablet (atenolol/chlorthalidone 100 mg-25 mg) orally once a day if needed.

Renal Dose Adjustments

Chlorthalidone:
Chlorthalidone is not expected to be filtered into the renal tubule (its site of action) when the glomerular filtration rate is less than 10 mL/min.

Atenolol:
CrCl less than 15 mL/min: Maximum dosage of atenolol is 50 mg every other day.
CrCl 15 to 35 mL/min: Maximum dosage of atenolol is 50 mg a day.

Liver Dose Adjustments

Data not available

Dose Adjustments

Since atenolol is excreted via the kidneys, dosage should be adjusted in cases of severe impairment of renal function. No significant accumulation of atenolol occurs until creatinine clearance falls below 35 mL/min.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Atenolol is moderately hemodialyzable (20 to 50%). Patients should be given 25 to 50 mg after each hemodialysis.

Elimination is not enhanced via peritoneal dialysis. A supplemental dose is not needed with peritoneal dialysis.

Other Comments

When necessary, another antihypertensive agent may be added gradually beginning with 50 percent of the usual recommended starting dose to avoid an excessive fall in blood pressure.

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