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Aliskiren / Amlodipine / Hydrochlorothiazide Dosage

Applies to the following strengths: 150 mg-5 mg-12.5 mg; 300 mg-5 mg-12.5 mg; 300 mg-5 mg-25 mg; 300 mg-10 mg-12.5 mg; 300 mg-10 mg-25 mg

Usual Adult Dose for Hypertension

Initial dose: 1 tablet orally daily
The dosage may be increased after 2 weeks of therapy.

Maximum dose: Aliskiren/amlodipine/hydrochlorothiazide 300/10/25 mg orally daily

Comments:

Renal Dose Adjustments

CrCl less than 30 mL/min: Not recommended

CrCl greater than 30 mL/min: No adjustment recommended

Liver Dose Adjustments

Exposure to amlodipine is increased in patients with hepatic insufficiency. Lower doses should be considered in these patients.

Dose Adjustments

Precautions

US BOXED WARNING:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Patients should establish a routine pattern for taking aliskiren/amlodipine/hydrochlorothiazide, either with or without a meal. High-fat meals decrease absorption of aliskiren substantially.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.