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Trilisate

Generic Name: choline and magnesium trisalicylates (KOE-leen and mag-NEE-zee-um tri-sa-LI-si-lates)
Brand Name: Examples include Tricosal and Trilisate

Children and teenagers should not use aspirin, aspirin-containing, or aspirin-related medicines for flu symptoms or chickenpox without first consulting a doctor. A rare but serious illness known as Reye syndrome may occur. Trilisate contains an aspirin-related component.


Trilisate is used for:

Relieving signs and symptoms of rheumatoid arthritis, osteoarthritis, and acute shoulder pain. It may also be used to relieve mild to moderate pain and to reduce fever.

Trilisate is a salicylate. It works by reducing inflammation in the joints.

Do NOT use Trilisate if:

  • you are allergic to any ingredient in Trilisate or to nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen)
  • you have a blood-clotting disease (including von Willebrand disease), bleeding, or hemophilia
  • the patient is a child or teenager with flu symptoms or chickenpox
  • you are taking probenecid or sulfinpyrazone

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update: First Time Brand-to-Generic Switches

Before using Trilisate:

Some medical conditions may interact with Trilisate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have stomach problems, ulcers, fever, nasal polyps, stroke, bleeding in the brain, vitamin K deficiency, chickenpox, blood-clotting problems, liver or kidney problems, or the flu

Some MEDICINES MAY INTERACT with Trilisate. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Carbonic anhydrase inhibitors (eg, acetazolamide), insulin, meglitinide antidiabetics (eg, repaglinide), methotrexate, steroids (eg, dexamethasone), or valproic acid because the risk of their side effects may be increased by Trilisate
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), probenecid, or sulfinpyrazone because their the effectiveness may be decreased by Trilisate

This may not be a complete list of all interactions that may occur. Ask your health care provider if Trilisate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Trilisate:

Use Trilisate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Trilisate by mouth with or without food. If stomach upset occurs, take with food or a large glass of milk to reduce stomach irritation.
  • Take Trilisate with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Trilisate.
  • If you miss a dose of Trilisate and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Trilisate.

Important safety information:

  • Trilisate may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Trilisate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Talk to your doctor before you take Trilisate if you drink more than 3 drinks with alcohol per day.
  • Trilisate may cause stomach bleeding. Your risk may be greater if you drink alcohol while you are using Trilisate.
  • Trilisate has a salicylate in it. Before you start any new medicine, check the label to see if it has a salicylate in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Tell your doctor or dentist that you take Trilisate before you receive any medical or dental care, emergency care, or surgery.
  • Trilisate should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Trilisate while you are pregnant. Trilisate is found in breast milk. If you are or will be breast-feeding while you use Trilisate, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Trilisate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; headache; heartburn; indigestion; nausea; sweating; stomach pain; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or tarry stools; blood in the stool; confusion; flushing; hallucinations; hearing loss; ringing in the ears; severe stomach pain; unusual bruising, bleeding, or black stools; vomit that looks like coffee grounds; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bloody stools; disorientation; drowsiness; general body discomfort; hallucinations; loss of consciousness; nausea; ringing in the ears; seizures; stupor; upset stomach; vomiting; wheezing.

Proper storage of Trilisate:

Store Trilisate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Trilisate out of the reach of children and away from pets.

General information:

  • If you have any questions about Trilisate, please talk with your doctor, pharmacist, or other health care provider.
  • Trilisate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Trilisate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Trilisate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Trilisate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Trilisate.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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