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Ticarcillin/ clavulanate

Generic Name: ticarcillin/clavulanate (TYE-kar-SIL-in/KLAV-ue-LAN-ate)
Brand Name: Timentin

Ticarcillin/ clavulanate is used for:

Treating infections caused by certain bacteria.

Ticarcillin/clavulanate is a penicillin antibiotic. It works by killing sensitive bacteria.

Do NOT use ticarcillin/ clavulanate if:

  • you are allergic to any ingredient in ticarcillin/clavulanate, to other penicillin antibiotics (eg, amoxicillin), or to any other beta lactam antibiotics, such as cephalosporins (eg, cephalexin)

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: The Shocking Truth About Antibiotic Resistance

Before using ticarcillin/ clavulanate:

Some medical conditions may interact with ticarcillin/clavulanate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems, bleeding or clotting problems, heart failure, or abnormal blood electrolyte levels (eg, low blood potassium levels)
  • if you have low blood volume or are dehydrated
  • if you are on a low-salt diet

Some MEDICINES MAY INTERACT with ticarcillin/clavulanate. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, heparin, warfarin) because the risk of bleeding may be increased
  • Probenecid because it may increase the risk of ticarcillin/clavulanate's side effects
  • Tetracyclines (eg, doxycycline) because they may decrease ticarcillin/clavulanate's effectiveness
  • Methotrexate because the risk of its side effects may be increased by ticarcillin/clavulanate
  • Aminoglycosides (eg, gentamicin), mycophenolate, or oral contraceptives (eg, birth control pills) because their effectiveness may be decreased by ticarcillin/clavulanate

This may not be a complete list of all interactions that may occur. Ask your health care provider if ticarcillin/clavulanate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ticarcillin/ clavulanate:

Use ticarcillin/clavulanate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Ticarcillin/clavulanate is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using ticarcillin/clavulanate at home, a health care provider will teach you how to use it. Be sure you understand how to use ticarcillin/clavulanate. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use ticarcillin/clavulanate if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • To clear up your infection completely, use ticarcillin/clavulanate for the full course of treatment. Keep taking it even if you feel better in a few days.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of ticarcillin/clavulanate, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use ticarcillin/clavulanate.

Important safety information:

  • Ticarcillin/clavulanate only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Be sure to use ticarcillin/clavulanate for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of ticarcillin/clavulanate may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Ticarcillin/clavulanate may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Tell your doctor or dentist that you take ticarcillin/clavulanate before you receive any medical or dental care, emergency care, or surgery.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using ticarcillin/clavulanate. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Do not receive a live vaccine (eg, oral typhoid vaccine) while you are taking ticarcillin/clavulanate. Talk with your doctor before you receive any vaccine.
  • Ticarcillin/clavulanate may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using ticarcillin/clavulanate.
  • Use ticarcillin/clavulanate with caution in the ELDERLY; they may be more sensitive to its effects.
  • Ticarcillin/clavulanate should be used with extreme caution in CHILDREN younger than 3 months old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using ticarcillin/clavulanate while you are pregnant. It is not known if ticarcillin/clavulanate is found in breast milk. If you are or will be breast-feeding while you use ticarcillin/clavulanate, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of ticarcillin/ clavulanate:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in taste and smell; gas; headache; mild diarrhea or stomach pain; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; chest pain; dark or bloody urine; fever, chills, or persistent sore throat; irregular heartbeat; joint pain; muscle pain, weakness, or cramping; pain, burning, swelling, or redness at the injection site; persistent painful urination; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea; severe stomach pain or cramps; swelling or soreness of the mouth or tongue; unusual bruising or bleeding; vaginal irritation or discharge; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of ticarcillin/clavulanate:

Ticarcillin/clavulanate is usually handled and stored by a health care provider. If you are using ticarcillin/clavulanate at home, store ticarcillin/clavulanate as directed by your pharmacist or health care provider. Keep ticarcillin/clavulanate out of the reach of children and away from pets.

General information:

  • If you have any questions about ticarcillin/clavulanate, please talk with your doctor, pharmacist, or other health care provider.
  • Ticarcillin/clavulanate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take ticarcillin/clavulanate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ticarcillin/clavulanate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ticarcillin/clavulanate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using ticarcillin/clavulanate.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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