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Clavulanate / Ticarcillin Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 15, 2024.

Applies to clavulanate / ticarcillin: intravenous powder for injection, intravenous solution.

Important warnings This medicine can cause some serious health issues

You should not use this medication if you are allergic to any penicillin or cephalosporin antibiotic.

Get emergency medical help if you have any of these signs of an allergic reaction while taking clavulanate / ticarcillin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to clavulanate / ticarcillin: intravenous powder for injection, intravenous solution.

Hematologic

The risk of significant bleeding may be increased in patients over the age of 60 years, patients receiving cytotoxic chemotherapy, patients with preexisting thrombocytopenia, and azotemia, and patients undergoing surgical procedures.

Leukopenia has been reported in 23% of patients with liver disease receiving beta-lactam antibiotics.[Ref]

Hepatic

Gastrointestinal

Onset of pseudomembranous colitis symptoms has been reported during or after antibacterial therapy.[Ref]

Dermatologic

Local

Nervous system

Convulsions have been reported rarely, particularly in patients with renal dysfunction or those using high doses.[Ref]

Hypersensitivity

Renal

Musculoskeletal

Other

Respiratory

Metabolic

Some studies have shown a correlation between the degree of hypokalemia and the dose of ticarcillin in addition to the serum BUN/creatinine ratio. These findings suggest that dehydration and high doses may be risk factors for hypokalemia.[Ref]

Genitourinary

An increased incidence of vaginal yeast infections has been associated with penicillins.[Ref]

Psychiatric

References

1. Link AS, Jr (1985) "Efficacy and safety of ticarcillin plus clavulanic acid and piperacillin in patients with lower respiratory tract infections." Am J Med, 79, p. 86-7

2. Fass RJ, Copelan EA, Brandt JT, Moeschberger ML, Ashton JJ (1987) "Platelet-mediated bleeding caused by broad-spectrum penicillins." J Infect Dis, 155, p. 1242-8

3. Stuart JJ (1980) "Ticarcillin-induced hemorrhage in a patient with thrombocytosis." South Med J, 73, p. 1084-5

4. Gastineau D, Spector R, Philips D (1981) "Severe neutropenia associated with ticarcillin therapy." Ann Intern Med, 94, p. 711-2

5. Mostow SR, O'Brien RF (1985) "Safety and effectiveness of ticarcillin plus clavulanate potassium in treatment of lower respiratory tract infections." Am J Med, 79, p. 78-80

6. Sanders CV, Marier RL, Aldridge KE, Derks FW, Martin DH (1985) "Safety and effectiveness of ticarcillin plus clavulanic acid in the treatment of community-acquired acute pyelonephritis in adult women." Am J Med, 79, p. 96-100

7. Gentry LO, Macko V, Lind R, Heilman A (1985) "Ticarcillin plus clavulanic acid (timentin) therapy for osteomyelitis." Am J Med, 79, p. 116-21

8. Croydon EA, Hermoso C (1986) "An evaluation of the safety and tolerance to timentin." J Antimicrob Chemother, 17, p. 233-40

9. Meylan PR, Calandra T, Casey PA, Glauser MP (1986) "Clinical experience with timentin in severe hospital infections." J Antimicrob Chemother, 17, p. 127-39

10. Tehan S, Horobin J, Gordonsmith R, McLatchie GR (1988) "Ticarcillin plus clavulanic acid (timentin): further UK trial results." Br J Clin Pract, 42, p. 8-16

11. (2001) "Product Information. Timentin (ticarcillin-clavulanate)." SmithKline Beecham

12. Shenep JL, Hughes WT, Roberson PK, et al. (1988) "Vancomycin, ticarcillin, and amikacin compared with ticarcillin-clavulanate and amikacin in the empirical treatment of febrile, neutropenic children with cancer." N Engl J Med, 319, p. 1053-8

13. Westenfelder M, Pelz K, Hulla FW (1986) "Clinical evaluation of timentin in complicated urinary tract infections." J Antimicrob Chemother, 17, p. 97-102

14. Schwigon CD, Hulla FW, Schulza B, Maslak A (1986) "Timentin in the treatment of nosocomial bronchopulmonary infections in intensive care units." J Antimicrob Chemother, 17, p. 115-22

15. Ryan J, Dudley FJ (1992) "Cholestasis with ticarcillin-potassium clavulanate (timentin)." Med J Aust, 156, p. 291

16. Sweet JM, Jones MP (1995) "Intrahepatic cholestasis due to ticarcillin-clavulanate." Am J Gastroenterol, 90, p. 675-6

17. Ramakrishnan K, Scheid DC (2005) "Diagnosis and management of acute pyelonephritis in adults." Am Fam Physician, 71, p. 933-42

18. Brown LA, Goldberg ND, Shearer WT (1982) "Long-term ticarcillin desensitization by the continuous oral administration of penicillin." J Allergy Clin Immunol, 69, p. 51-4

19. Welter J, Wittman DH, Freitag V (1981) "Ticarcillin therapy of risk patients with infections due to pseudomonas aeruginosa." J Int Med Res, 9, p. 44-51

20. Finch RA (1981) "Hypernatremia during lithium and ticarcillin therapy." South Med J, 74, p. 376-7

21. Ramirez-Ronda CH, Gutierrez J, Bermudez RH (1982) "Comparative effectiveness, safety and tolerance of mezlocillin and ticarcillin: a prospective randomized trial." J Antimicrob Chemother, 9, p. 125-9

22. Nanji AA, Lindsay J (1982) "Ticarcillin associated hypokalemia." Clin Biochem, 15, p. 118-9

Further information

Clavulanate/ticarcillin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.