Liothyronine

Pronunciation

Generic Name: liothyronine (lye-oh-THYE-roe-neen)
Brand Name: Triostat

Liothyronine, used alone or in combination with other medicines, should not be used to treat obesity or for weight loss. Large doses may cause serious or life-threatening toxic effects, particularly when used with other medicines that reduce the appetite.


Liothyronine is used for:

Treating myxedema coma or precoma (life-threatening symptoms caused by low thyroid levels). It may also be used for other conditions as determined by your doctor.

Liothyronine is a thyroid hormone. It works by supplementing the natural thyroid hormones in the body.

Do NOT use liothyronine if:

  • you are allergic to any ingredient in liothyronine
  • you have untreated thyrotoxicosis (high thyroid levels) or untreated adrenal cortical problems (eg, Addison disease), or you have a history of heart attack

Contact your doctor or health care provider right away if any of these apply to you.

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Before using liothyronine:

Some medical conditions may interact with liothyronine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are planning to have surgery
  • if you have heart or blood vessel disease (eg, angina), high blood pressure, an overactive thyroid, or a long-standing condition of underactive thyroid

Some MEDICINES MAY INTERACT with liothyronine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Estrogen or oral contraceptives (birth control pills) because they may decrease liothyronine's effectiveness
  • Anticoagulants (eg, warfarin), ketamine, tricyclic antidepressants (eg, amitriptyline), or vasopressors (eg, epinephrine) because their actions and the risk of their side effects may be increased by liothyronine
  • Insulin, oral hypoglycemics (eg, glipizide), or digitalis glycosides (eg, digoxin) because their effectiveness may be decreased by liothyronine

This may not be a complete list of all interactions that may occur. Ask your health care provider if liothyronine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use liothyronine:

Use liothyronine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Liothyronine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using liothyronine at home, a health care provider will teach you how to use it. Be sure you understand how to use liothyronine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use liothyronine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of liothyronine, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use liothyronine.

Important safety information:

  • Check with your doctor if you experience trembling or shaking of the hands, nervousness, difficulty sleeping, headache, change in appetite, diarrhea, weight loss, increased sweating, increased sensitivity to heat, increased heart rate, chest pain, or shortness of breath. These symptoms may mean that your dose needs to be adjusted. Do not adjust your dose or stop taking liothyronine without checking with your doctor.
  • Diabetes patients - Liothyronine may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests, including thyroid function tests, may be performed while you use liothyronine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use liothyronine with caution in the ELDERLY; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using liothyronine while you are pregnant. Liothyronine is found in breast milk. If you are or will be breast-feeding while you use liothyronine, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of liothyronine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Fever; pain or irritation at the injection site; twitching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fast or irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; fast heartbeat; nervousness; stomach cramps; trouble sleeping; weight loss.

Proper storage of liothyronine:

Store liothyronine in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Keep liothyronine, as well as syringes and needles, out of the reach of children and away from pets.

General information:

  • If you have any questions about liothyronine, please talk with your doctor, pharmacist, or other health care provider.
  • Liothyronine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take liothyronine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about liothyronine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to liothyronine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using liothyronine.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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