Medication Guide App

Generic Name: trazodone (TRAZ-oh-done)
Brand Name: Generic only. No brands available.

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Desyrel outweigh the risks.

Families and caregivers must closely watch patients who take Desyrel. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Desyrel is not approved for use in children. Talk with the doctor.


Desyrel is used for:

Treating depression. It may also be used for relief of an anxiety disorder (eg, sleeplessness, tension), chronic pain. It may also be used for other conditions as determined by your doctor.

Desyrel is an antidepressant. It is thought to work by increasing the activity of one of the brain chemicals (serotonin), which helps elevate mood.

Do NOT use Desyrel if:

  • you are allergic to any ingredient in Desyrel or to nefazodone
  • you have had a recent heart attack
  • you are taking or have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Desyrel:

Some medical conditions may interact with Desyrel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you or a family member has a history of bipolar disorder (manic-depression), other mental or mood problems (eg, depression), suicidal thoughts or attempts, alcohol or substance abuse, or a certain type of irregular heartbeat (QT prolongation)
  • if you have liver problems, kidney problems, low blood sodium levels, low blood potassium levels, low blood magnesium levels, heart problems, low blood pressure, or increased eye pressure or glaucoma
  • if you have sickle cell anemia, multiple myeloma, or leukemia, or if you have a deformed penis (eg, angulation, cavernosal fibrosis, Peyronie disease)
  • if you are scheduled to have surgery, if you are dehydrated, or if you drink alcohol
  • if you are taking a medicine that contains methylene blue
  • if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Desyrel. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of bleeding may be increased
  • Antipsychotics (eg, olanzapine, haloperidol), buspirone, fentanyl, linezolid, lithium, MAOIs, (eg, phenelzine), methylene blue, phenothiazines (eg, thioridazine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine, venlafaxine), St. John's wort, tramadol, tricyclic antidepressants (eg, amitriptyline), "triptans" (eg, sumatriptan), or tryptophan because severe side effects, such as a reaction that may include fever, rigid muscles, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, or coma, may occur
  • Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood sodium levels may be increased
  • Azole antifungals (eg, itraconazole, ketoconazole), delavirdine, HIV protease inhibitors (eg, indinavir, ritonavir), or perampanel because they may increase the risk of Desyrel's side effects
  • Carbamazepine because it may decrease Desyrel's effectiveness
  • Amiodarone, barbiturates (eg, phenobarbital), digoxin, hydantoins (eg, phenytoin), nefazodone, sodium oxybate (GHB), or medicine for high blood pressure because the risk of their side effects may be increased by Desyrel

This may not be a complete list of all interactions that may occur. Ask your health care provider if Desyrel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Desyrel:

Use Desyrel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Desyrel comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Desyrel refilled.
  • Take Desyrel shortly after a meal or light snack.
  • It may take 1 to 4 weeks for Desyrel to work. Do not stop taking Desyrel without checking with your doctor.
  • If you miss a dose of Desyrel, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Desyrel.

Important safety information:

  • Desyrel may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Desyrel with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Desyrel; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Desyrel may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Children, teenagers, and young adults who take Desyrel may be at increased risk for suicidal thoughts or actions. Watch all patients who take Desyrel closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • Serotonin syndrome is a possibly fatal syndrome that can be caused by Desyrel. Your risk may be greater if you take Desyrel with certain other medicines (eg, "triptans," MAOIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
  • Certain antidepressants, including Desyrel, may increase the risk of bleeding. Sometimes, bleeding can be life-threatening. Discuss any questions or concerns with your doctor.
  • Some people may be at risk for eye problems from Desyrel. Your doctor may want you to have an eye exam to see if you are at risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, or swelling or redness in or around the eye.
  • Tell your doctor or dentist that you take Desyrel before you receive any medical or dental care, emergency care, or surgery.
  • Desyrel may rarely cause a prolonged, painful erection (priapism). This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.
  • Use Desyrel with caution in the ELDERLY; they may be more sensitive to its effects, especially low blood sodium levels.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Desyrel while you are pregnant. Desyrel is found in breast milk. If you are or will be breast-feeding while you use Desyrel, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Desyrel:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; light-headedness when sitting up or standing; muscle aches or pains; nausea; nervousness; stomach pain; stuffy nose; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; bloody or dark urine; chest pain; decreased coordination; decreased sexual desire or ability; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; new or worsening agitation, anxiety, depression, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, trouble sleeping, or inability to sit still; prolonged, inappropriate, or painful erections; seizures; severe or persistent dizziness or tiredness; shortness of breath; speech problems; suicidal thoughts or actions; swelling of the hands, ankles, or feet; symptoms of low blood sodium levels (eg, confusion, persistent headache, trouble concentrating, memory problems, weakness, unsteadiness, sluggishness, personality changes); tremor; unusual bruising or bleeding; unusual weight changes; vomit that looks like coffee grounds; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Desyrel:

Store Desyrel at room temperature, between 68 and 77 degrees F (20 and 25 degrees C) in a tight, light-resistant container. Store away from heat, moisture, and light. Protect from temperatures above 104 degrees F (40 degrees C). Do not store in the bathroom. Keep Desyrel out of the reach of children and away from pets.

General information:

  • If you have any questions about Desyrel, please talk with your doctor, pharmacist, or other health care provider.
  • Desyrel is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Desyrel or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Desyrel. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Desyrel. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Desyrel.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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