Generic Name: fondaparinux (fon-DAP-a-rin-ux)
Brand Name: Arixtra
Tell your doctor you use Arixtra before you have any type of spinal or epidural procedure. Patients who have these procedures while they use Arixtra are at risk for developing bleeding around your spine. This could result in long-term or permanent paralysis.
The risk is increased in patients who have an indwelling epidural catheter. It is also increased in patients with a history of traumatic or repeated epidural or spinal puncture, a deformed spine, or spinal surgery. It is also increased in patients who use medicines that may affect blood clotting, such as other anticoagulants (eg, warfarin), aspirin, platelet inhibitors (eg, clopidogrel), and nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen).
If you have a spinal or epidural procedure while you use Arixtra, tell your doctor at once if you notice any symptoms of nerve problems (eg, back pain; numbness or tingling, especially in the legs and feet; muscle weakness; paralysis; loss of bladder or bowel control).
Talk with your doctor if you have recently had or will be having a spinal or epidural procedure. Some time may need to pass between the use of Arixtra and your procedure. Discuss any questions or concerns with your doctor
Arixtra is used for:
Preventing blood clots in patients who will be having certain types of surgery. Arixtra is also used with warfarin to treat blood clots in the leg or lungs. It may also be used for other conditions as determined by your doctor.
Arixtra is an anticoagulant. It works by inhibiting one of the steps necessary for the formation of blood clots, which helps prevent clots from developing or worsening.
Do NOT use Arixtra if:
- you are allergic to any ingredient in Arixtra
- you have severe kidney problems, inflammation of the heart due to a bacterial infection (eg, bacterial endocarditis), active major bleeding, or severe bleeding problems
- you have a low platelet count and the presence of antiplatelet antibodies
- you weigh less than 110 pounds (50 kg) and are using Arixtra to treat a blood clot in the lungs or legs
- you weigh less than 110 pounds (50 kg) and will be having hip or knee replacement surgery or abdominal surgery, or you have had a hip fracture
Contact your doctor or health care provider right away if any of these apply to you.
Before using Arixtra:
Some medical conditions may interact with Arixtra. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances (eg, latex)
- if you have a history of kidney problems, liver problems, stomach or intestinal problems (eg, ulcers), stroke, or vision problems caused by diabetes
- if you have a bleeding disorder; a history of brain bleeding or blood conditions; severe, uncontrolled high blood pressure; or low body weight
- if you have recently had or are scheduled to have brain, spine, or eye surgery; an epidural catheter; or a spinal puncture
- if you are taking medicines that affect platelets (eg, aspirin, clopidogrel, ticlopidine)
Some MEDICINES MAY INTERACT with Arixtra. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Activated protein C (eg, drotrecogin alfa), anticoagulants (eg, warfarin), direct factor Xa inhibitors (eg, rivaroxaban), direct thrombin inhibitors (eg, dabigatran), NSAIDs (eg, ibuprofen, ketorolac, naproxen), platelet inhibitors (eg, clopidogrel, ticlopidine), or salicylates (eg, aspirin) because they may increase the risk of bleeding
This may not be a complete list of all interactions that may occur. Ask your health care provider if Arixtra may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Arixtra:
Use Arixtra as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Arixtra. Talk to your pharmacist if you have questions about this information.
- Arixtra is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Arixtra at home, a health care provider will teach you how to use it. Be sure you understand how to use Arixtra. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Arixtra if it contains particles, is cloudy or discolored, or if the syringe is cracked or damaged.
- Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into muscle.
- Use a different injection site each day to prevent problems at the injection site (eg, hematomas).
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Arixtra, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Arixtra.
Important safety information:
- Arixtra may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Tell your doctor or dentist that you take Arixtra before you receive any medical or dental care, emergency care, or surgery.
- Before you begin taking any new prescription or nonprescription medicine, check the label to see if it has aspirin or ibuprofen in it. If it does or you are not sure, contact your doctor or pharmacist.
- Arixtra may affect certain lab tests, including liver enzyme. Be sure your doctor and lab personnel know you are using Arixtra.
- Lab tests, including complete blood cell counts (eg, platelet counts), kidney function, and stool blood, may be performed while you use Arixtra. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Arixtra with caution in the ELDERLY; they may be more sensitive to its effects, especially bleeding.
- Arixtra should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. Children may have an increased risk of bleeding with Arixtra.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Arixtra while you are pregnant. It is not known if Arixtra is found in breast milk. If you are or will be breast-feeding while you use Arixtra, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Arixtra:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Mild bleeding, irritation, rash, or itching at the injection site; trouble sleeping.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody, black, tarry stools; confusion; difficulty walking; fainting; fever; increased drainage or oozing from a wound; loss of appetite; nosebleed; one-sided weakness; pale skin; pink or red urine; severe or persistent dizziness or headache; severe or persistent tiredness, weakness, nausea, or vomiting; slurred speech; swelling of the ankles, feet, or hands; tingling or numbness (especially in the legs and feet), and muscle weakness; unusual or severe bleeding or bruising; vomit that looks like coffee grounds.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive bleeding and bruising.Proper storage of Arixtra:
Store Arixtra at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Arixtra out of the reach of children and away from pets.
- If you have any questions about Arixtra, please talk with your doctor, pharmacist, or other health care provider.
- Arixtra is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Arixtra or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Arixtra. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Arixtra. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Arixtra.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.