Fondaparinux Pregnancy and Breastfeeding Warnings

Fondaparinux is also known as: Arixtra, Arixtra 10 mg/dose, Arixtra 5 mg/dose, Arixtra 7.5 mg/dose

Fondaparinux Pregnancy Warnings

Fondaparinux has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of impaired fertility or harm to the fetus due to fondaparinux. There are no controlled data in human pregnancy. Fondaparinux is only recommended for use during pregnancy when benefit outweighs risk.

An in vitro study suggests that fondaparinux does not cross the placental barrier based on results of placental transfer using a human cotyledon model.

Fondaparinux Breastfeeding Warnings

Fondaparinux was found to be excreted in the milk of lactating rats.

There are no data on the excretion of fondaparinux into human milk. The effects in the nursing infant are unknown. The manufacturer recommends that caution be used when administering fondaparinux to nursing women.

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