Arixtra Side Effects

Generic Name: fondaparinux

Note: This document contains side effect information about fondaparinux. Some of the dosage forms listed on this page may not apply to the brand name Arixtra.

Some side effects of Arixtra may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to fondaparinux: subcutaneous solution

Along with its needed effects, fondaparinux (the active ingredient contained in Arixtra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fondaparinux:

More common
  • Pale skin
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Black, tarry stools
  • bladder pain
  • bleeding
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • chest pain
  • chills
  • collection of blood under the skin
  • confusion
  • convulsions
  • cough
  • decreased or cloudy urine
  • deep, dark purple bruise
  • difficult, burning, or painful urination
  • dizziness
  • dry mouth
  • fainting or lightheadedness when getting up from a lying or sitting position
  • fever
  • frequent urge to urinate
  • increased thirst
  • irregular heartbeat
  • itching, pain, redness, or swelling at the place of injection
  • loss of appetite
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pinpoint red spots on the skin
  • red, tender, or oozing skin at incision
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden sweating

Get emergency help immediately if any of the following symptoms of overdose occur while taking fondaparinux:

Symptoms of overdose
  • Abdominal or stomach pain or swelling
  • bruising or purple areas on the skin
  • coughing up blood
  • decreased alertness
  • headache
  • joint pain or swelling
  • nosebleeds

Some side effects of fondaparinux may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty having a bowel movement
  • rash
  • sleeplessness
  • swelling
  • trouble sleeping
Less common
  • Acid or sour stomach
  • belching
  • diarrhea
  • heartburn
  • indigestion
  • pain
  • skin blisters
  • stomach discomfort, upset, or pain
  • tightness in the chest
  • unusual changes to site of surgery
  • wheezing
  • wound drainage, increased

For Healthcare Professionals

Applies to fondaparinux: subcutaneous solution

Hematologic

Hematologic side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra) have included major bleeding, anemia, purpura, thrombocytopenia, postoperative hemorrhage and hematoma. Occurrences of major bleeding in patients receiving therapeutic regimen in treatment of DVT and PE with normal renal function, mild renal impairment, moderate renal impairment, and severe renal impairment have been found to be 0.4%, 1.6%, 2.2%, and 7.3%, respectively. Moderate thrombocytopenia occurred at a rate of 0.5% in patients given fondaparinux treatment regimen in the DVT and PE treatment clinical trials. Severe thrombocytopenia occurred at a rate of 0.04% in patients given fondaparinux treatment regimen in the DVT and PE treatment clinical trials.

Rare cases of elevated aPTT and heparin-induced thrombocytopenia have been reported. A causal relationship of these events to fondaparinux has not been established.

Hepatic

Hepatic side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra) have included elevated aminotransferase levels.

Local

Local side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra) have included injection site bleeding, rash, and pruritus.

Gastrointestinal

Gastrointestinal side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra) have included nausea, vomiting, constipation, diarrhea, and dyspepsia.

Nervous system

Nervous system side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra) have included insomnia, dizziness, and confusion.

Dermatologic

Dermatologic side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra) have included rash, increased wound drainage, and bullous eruption.

Cardiovascular

Cardiovascular side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra) have included hypotension and edema.

Genitourinary

Genitourinary side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra) have included urinary tract infection and urinary retention.

Metabolic

Metabolic side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra) have included hypokalemia.

Other

Other side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra) have included fever, headache, and pain.

Hypersensitivity

Hypersensitivity side effects include postmarketing reports of serious allergic reactions including angioedema and anaphylactoid/anaphylactic reactions.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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