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Aprepitant

Generic Name: aprepitant (a-PRE-pi-tant)
Brand Name: Emend

Aprepitant is used for:

Preventing nausea and vomiting caused by certain types of cancer medicines (chemotherapy). It is used in combination with other medicines. It is also used to prevent nausea and vomiting after surgery. It may also be used for other conditions as determined by your doctor.

Aprepitant is an antiemetic. It works by blocking certain substances in the brain, which helps to prevent nausea and vomiting.

Do NOT use aprepitant if:

  • you are allergic to any ingredient in aprepitant
  • you are taking bosutinib, cisapride, lomitapide, pimozide, or tolvaptan

Contact your doctor or health care provider right away if any of these apply to you.

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Before using aprepitant:

Some medical conditions may interact with aprepitant. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems
  • if you currently have nausea or vomiting

Some MEDICINES MAY INTERACT with aprepitant. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for allergies, anxiety, birth control, blood thinning, cancer, chest pain, cystic fibrosis, depression or other mental or mood problems, erectile dysfunction, gout, high blood pressure, HIV, immune system suppression, infections, inflammation, irregular heartbeat or other heart problems, pain, seizures), multivitamin products, or herbal or dietary supplements because they may interact with aprepitant. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with aprepitant

This may not be a complete list of all interactions that may occur. Ask your health care provider if aprepitant may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use aprepitant:

Use aprepitant as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with aprepitant. Talk to your pharmacist if you have questions about this information.
  • Take aprepitant by mouth with or without food.
  • Do not start aprepitant if you already have nausea or vomiting before you take it. Tell your doctor.
  • It is important to follow your doctor's instructions for the timing of each dose and for the length of treatment. If you are not sure how or when to take aprepitant, check with your doctor.
  • If you miss a dose of aprepitant, contact your doctor right away.

Ask your health care provider any questions you may have about how to use aprepitant.

Important safety information:

  • Aprepitant may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use aprepitant with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using aprepitant. To prevent pregnancy, be sure to use an extra form of birth control (eg, condoms) while using aprepitant and for 1 month following the last dose of aprepitant.
  • Use aprepitant with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using aprepitant while you are pregnant. It is not known if aprepitant is found in breast milk. Do not breast-feed while taking aprepitant.

Possible side effects of aprepitant:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; hair loss; headache; heartburn; hiccups; loss of appetite; nausea; tiredness; upset stomach; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); burning, numbness, or tingling of your arms, hands, legs, or feet; burning or pain during urination; chest, jaw, or arm pain; confusion; difficult or decreased urination; fainting; fast, slow, or irregular heartbeat; flushing; mental or mood changes (eg, depression); pain, redness, or swelling in the legs; red, swollen, blistered, or peeling skin; severe or persistent dizziness, headache, heartburn, or stomach pain; severe rash with fever, mouth sores, or red and irritated eyes; signs of infection (eg, fever, chills, persistent sore throat); soreness of the mouth or tongue; shortness of breath; strong urge to urinate.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include drowsiness; headache.

Proper storage of aprepitant:

Store aprepitant at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep aprepitant out of the reach of children and away from pets.

General information:

  • If you have any questions about aprepitant, please talk with your doctor, pharmacist, or other health care provider.
  • Aprepitant is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take aprepitant or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about aprepitant. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to aprepitant. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using aprepitant.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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