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Aprepitant Pregnancy and Breastfeeding Warnings

Aprepitant is also known as: Emend, Emend 2-Day, Emend 3-Day

Aprepitant Pregnancy Warnings

FDA pregnancy category: B Use aprepitant only if clearly needed. Comments: Reduced efficacy of hormonal contraceptives during and for 28 days following the last dose of aprepitant. Alternative or back-up contraception should be used during treatment and for 1 month following the last dose.

Animal reproduction studies have revealed no evidence of impaired fertility or harm to the fetus. There are no controlled data in human pregnancy. FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

Aprepitant Breastfeeding Warnings

There are no data on the excretion of aprepitant into human milk. Because many drugs are excreted in human milk, because of the potential for serious adverse reactions due to aprepitant in nursing infants, and the potential for tumorigenicity shown for aprepitant in rodent carcinogenicity studies, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See Also...

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