Aprepitant Dosage
This dosage information may not include all the information needed to use Aprepitant safely and effectively. See additional information for Aprepitant.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced
Initial dose: 125 mg orally one hour prior to chemotherapy on day 1.
The first dose is followed by 80 mg once daily in the morning on days 2 and 3.
Doses may be taken with or without food.
Aprepitant is administered for 3 days as part of a regimen that also includes a corticosteroid and a 5-HT3 antagonist. (In clinical studies, dexamethasone was administered on day 1 at 12 mg orally and days 2 through 4 at 8 mg orally. Ondansetron was also administered on day 1 at 32 mg IV.)
The antiemetic effectiveness in patients receiving the aprepitant regimen throughout repeated cycles has been reported to be maintained in each of the multiple cycles. However, chronic continuous dosing is not recommended.
Usual Adult Dose for Nausea/Vomiting - Postoperative
Recommended dose: a single, oral 40 mg dose administered within 3 hours prior to the induction of anesthesia
Renal Dose Adjustments
No dosage adjustment is necessary in patients with renal insufficiency.
Liver Dose Adjustments
No dosage adjustment is necessary for patients with mild to moderate hepatic insufficiency (Child-Pugh score 5 to 9). There are no clinical data on patients with severe hepatic insufficiency (Child-Pugh score >9).
Dialysis
No dosage adjustment is necessary in patients with renal insufficiency.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
