Medication Guide App

Aprepitant Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced

HIGHLY EMETOGENIC CANCER CHEMOTHERAPY:
Day 1: 125 mg orally 1 hour prior to chemotherapy
Day 2 and 3: 80 mg orally in the morning
Duration of therapy: Three days
Comments:
-Aprepitant is administered in conjunction with a corticosteroid and a 5-HT3 antagonist.
-The recommended dosage of dexamethasone is 12 mg orally on day 1 administered 30 minutes prior to chemotherapy and 8 mg orally in the mornings on days 2 through 4.
-The 5-HT3 antagonist is administered on day 1 only. Consult the package insert for the 5-HT3 antagonist dosing prior to initiation of treatment.
-Aprepitant may be taken with or without food.

Fosaprepitant dimeglumine for Injection (115 mg) may be substituted for oral aprepitant (125 mg), 30 minutes prior to chemotherapy, on Day 1 only of the CINV regimen as an intravenous infusion administered over 15 minutes.

MODERATELY EMETOGENIC CANCER CHEMOTHERAPY:
Day 1: 125 mg orally 1 hour prior to chemotherapy
Day 2 and 3: 80 mg orally in the morning
Duration of therapy: Three days
Comments:
-Aprepitant is administered in conjunction with a corticosteroid and a 5-HT3 antagonist.
-The recommended dosage of dexamethasone is 12 mg orally on day 1 administered 30 minutes prior to chemotherapy.
-The 5-HT3 antagonist is administered on day 1 only. Consult the package insert for the 5-HT3 antagonist dosing prior to initiation of treatment.
-Aprepitant may be taken with or without food.

Usual Adult Dose for Nausea/Vomiting - Postoperative

Recommended dose: a single, oral 40 mg dose administered within 3 hours prior to the induction of anesthesia

Renal Dose Adjustments

No dosage adjustment is necessary in patients with renal insufficiency.

Liver Dose Adjustments

Mild to moderate liver dysfunction: No adjustment recommended.
Severe liver dysfunction (Child-Pugh C): Data not available. Caution recommended.

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Aprepitant is nondialyzable. No dosage adjustment is necessary for patients with end stage renal disease (ESRD) undergoing hemodialysis.

Other Comments

Administration advice:
-For prevention of CINV, take first dose 1 hour prior to chemotherapy.
-For prevention of PONV, receive medication within 3 hours prior to induction of anesthesia.

Patient advice:
-Report to doctor the use of any other prescription, non-prescription medication or herbal products.
-Patients on chronic warfarin therapy should have their clotting status closely monitored.
-Patients should use alternative or back-up methods of contraception during treatment and for 1 month following the last dose.

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