droperidol

Pronunciation

Generic Name: droperidol (dro PER i dol)
Brand Name: Inapsine

What is droperidol?

Droperidol is a sedative, tranquilizer, and anti-nausea medication.

Droperidol is used to reduce nausea and vomiting caused by surgery or other medical procedures.

Droperidol may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about droperidol?

You should not use this medication if you are allergic to droperidol, or have a personal or family history of "Long QT syndrome."

Before you receive droperidol, tell your doctor if you have heart disease, high blood pressure, a heart rhythm disorder, low potassium, liver or kidney disease, adrenal gland cancer, or a history of alcohol abuse.

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Before you receive droperidol, tell your doctor if you have been taking any medications to treat high blood pressure, a heart rhythm disorder, malaria, infections, a prostate disorder, depression or mental illness, or if you are using a narcotic pain medication.

What should I discuss with my health care provider before receiving droperidol?

You should not be given this medication if you are allergic to droperidol, or have a personal or family history of "Long QT syndrome."

Before you receive droperidol, tell your doctor if you are allergic to any drugs, or if you have:

  • heart disease;

  • heart rhythm disorder;

  • congestive heart failure;

  • high blood pressure;

  • an electrolyte imbalance (such as low potassium);

  • liver or kidney disease;

  • adrenal gland cancer (pheochromocytoma); or

  • a history of alcohol abuse.

If you have any of these conditions, you may not be able to receive droperidol, or you may need a dose adjustment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Before you receive droperidol, tell your doctor if you are pregnant.

It is not known whether droperidol passes into breast milk or if it could harm a nursing baby. Before you receive this medication, tell your doctor if you are breast-feeding a baby.

How is droperidol given?

Droperidol is given as an injection through a needle placed into a muscle or a vein. You will receive this injection in a clinic or hospital setting prior to and/or during your surgery or medical procedure.

What happens if I miss a dose?

Since droperidol is given as needed by a healthcare professional, it is not likely that you will miss a dose.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

Overdose symptoms may include fast or pounding heartbeats, dizziness, uneven heart rate, or fluttering in your chest.

What should I avoid after receiving droperidol?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by droperidol. Tell your doctor if you have been taking any of these other medicines before you receive droperidol.

Droperidol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • feeling like you might pass out;

  • dizziness, fainting, fast or pounding heartbeat, fluttering in your chest;

  • chest tightness and trouble breathing;

  • fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;

  • confusion, hallucinations;

  • tremor (uncontrolled shaking); or

  • restless muscle movements in your eyes, tongue, jaw, or neck.

Less serious side effects include:

  • drowsiness, dizziness; or

  • feeling restless or anxious.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Droperidol Dosing Information

Usual Adult Dose for Nausea/Vomiting:

To reduce the incidence of nausea and vomiting associated with surgical and diagnostic procedures:

Dosage: The dosage should be individualized. Factors to be considered in determining dose are age, body weight, physical status, underlying pathological condition, use of other drugs, the type of anesthesia to be used, and the surgical procedure involved. Vital signs and ECG should be monitored closely.

Maximum Dosage: The maximum recommended initial dose is 2.5 mg IM or slow IV. Additional 1.25 mg doses of droperidol may be administered to achieve the desired effect. The additional doses should be administered with caution and only if the potential benefit outweighs the potential risk.

Usual Adult Dose for Nausea/Vomiting -- Postoperative:

To reduce the incidence of nausea and vomiting associated with surgical and diagnostic procedures:

Dosage: The dosage should be individualized. Factors to be considered in determining dose are age, body weight, physical status, underlying pathological condition, use of other drugs, the type of anesthesia to be used, and the surgical procedure involved. Vital signs and ECG should be monitored closely.

Maximum Dosage: The maximum recommended initial dose is 2.5 mg IM or slow IV. Additional 1.25 mg doses of droperidol may be administered to achieve the desired effect. The additional doses should be administered with caution and only if the potential benefit outweighs the potential risk.

Usual Pediatric Dose for Nausea/Vomiting:

To reduce the incidence of nausea and vomiting associated with surgical and diagnostic procedures:

Dosage: The dosage should be individualized. Factors to be considered in determining dose are age, body weight, physical status, underlying pathological condition, use of other drugs, the type of anesthesia to be used, and the surgical procedure involved. Vital signs and ECG should be monitored closely.

Children 2 to 12 years:
Postoperative nausea and vomiting (PONV):
Prophylaxis, if high risk for PONV: 0.01 to 0.015 mg/kg/dose IM or IV given near the end of surgery Maximum dose: 1.25 mg
Administer additional doses after at least 6 hours with caution and only if potential benefit outweighs risks.
(Previous reports suggested a higher dose of 0.075 mg/kg as effective; however, due to side effects associated with the higher doses, doses greater than 0.05 mg/kg are considered excessive and no longer recommended.)

Treatment (not first line): IV:
Manufacturer recommendations: 0.1 mg/kg/dose. Administer additional doses with extreme caution and only if potential benefit outweighs risks.

Alternate dosing: Doses as low as 0.01 to 0.015 mg/kg/dose (up to 0.03 mg/kg) may be effective for breakthrough nausea and vomiting
Maximum initial dose: 0.1 mg/kg
Administer additional doses after at least 6 hours with caution and only if potential benefit outweighs risks.

Usual Pediatric Dose for Nausea/Vomiting -- Postoperative:

To reduce the incidence of nausea and vomiting associated with surgical and diagnostic procedures:

Dosage: The dosage should be individualized. Factors to be considered in determining dose are age, body weight, physical status, underlying pathological condition, use of other drugs, the type of anesthesia to be used, and the surgical procedure involved. Vital signs and ECG should be monitored closely.

Children 2 to 12 years:
Postoperative nausea and vomiting (PONV):
Prophylaxis, if high risk for PONV: 0.01 to 0.015 mg/kg/dose IM or IV given near the end of surgery Maximum dose: 1.25 mg
Administer additional doses after at least 6 hours with caution and only if potential benefit outweighs risks.
(Previous reports suggested a higher dose of 0.075 mg/kg as effective; however, due to side effects associated with the higher doses, doses greater than 0.05 mg/kg are considered excessive and no longer recommended.)

Treatment (not first line): IV:
Manufacturer recommendations: 0.1 mg/kg/dose. Administer additional doses with extreme caution and only if potential benefit outweighs risks.

Alternate dosing: Doses as low as 0.01 to 0.015 mg/kg/dose (up to 0.03 mg/kg) may be effective for breakthrough nausea and vomiting
Maximum initial dose: 0.1 mg/kg
Administer additional doses after at least 6 hours with caution and only if potential benefit outweighs risks.

What other drugs will affect droperidol?

The following drugs can interact with droperidol. Tell your doctor if you are using any of these:

  • arsenic trioxide (Trisenox);

  • a diuretic (water pill);

  • a laxative;

  • a drug to treat a psychiatric disorder;

  • an anti-malaria medication;

  • heart or blood pressure medications (Cartia XT, Procardia, Covera, Isoptin, Verelan and others);

  • heart rhythm medication such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), quinidine (Cardioquin, Quinaglute), sotalol (Betapace), and others;

  • drugs to treat high blood pressure or a prostate disorder, such as doxazosin (Cardura), or prazosin (Minipress);

  • an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);

  • a narcotic pain medication such as hydrocodone (Lortab, Vicodin), morphine (MS Contin), oxycodone (OxyContin, Percocet), propoxyphene (Darvocet, Darvon), and others; or

  • an antibiotic such as azithromycin (Zithromax), clarithromycin (Biaxin), erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab), and others.

This list is not complete and there may be other drugs that can interact with droperidol. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about droperidol.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.03. Revision Date: 2010-12-15, 5:01:39 PM.

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