Cobenfy: Uses, How It Works, and Common Side Effects

Cobenfy is a medication used to treat schizophrenia that works differently from other antipsychotics.

It was approved by the FDA in 2024.

This medication contains two ingredients, xanomeline and trospium chloride.

Xanomeline is a muscarinic agonist that works inside the brain to improve schizophrenia symptoms.

Trospium chloride is a muscarinic antagonist that works outside the brain to help reduce side effects caused by xanomeline.

Cobenfy is taken by mouth twice daily on an empty stomach.

The capsules should be taken at least 1 hour before or 2 hours after a meal, and should not be opened.

The most common side effects of Cobenfy are nausea, indigestion, constipation, vomiting, high blood pressure, stomach pain, diarrhea, fast heartbeat, and dizziness.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Always consult with your healthcare provider.

References:
1. Drugs.com. Updated Oct 2024. Cobenfy: Package Insert / Prescribing Info. Retrieved from https://www.drugs.com/pro/cobenfy.html
2. Cobenfy [package insert]. Updated Sept 2024. E.R. Squibb & Sons, L.L.C. Retrieved from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f0e73bf-6025-44f6-ab64-0983322de0df