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Vyxeos: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 2, 2024.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Vyxeos is a combination chemotherapy medicine that contains two commonly used drugs for AML - daunorubicin and cytarabine - which are encapsulated in liposomes (fat-like coatings that allow more of the active drug to reach the bone marrow cells and help to reduce the harmful effects of daunorubicin and cytarabine on healthy tissue). Vyxeos can cause side effects, such as bleeding (nose bleeds are common), neutropenia, and thrombocytopenia, and it should not be taken during pregnancy or while breastfeeding.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Vyxeos may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Vyxeos. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Vyxeos interacts with over 425 medications; the majority of these interactions are considered major or moderate. Common medications that may interact with Vyxeos include:

Cardiotoxic agents, such as 5-fluorouracil, targeted treatments (such as tyrosine kinase inhibitors), and paclitaxel may cause additive cardiotoxic effects and should be avoided.

Concomitant use with hepatotoxic agents can impair liver function and increase the toxicity of Vyxeos.

Note that this list is not all-inclusive and includes only common medications that may interact with Vyxeos. You should refer to the prescribing information for Vyxeos for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Vyxeos only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: January 1, 2024.