Yeztugo Side Effects
Generic name: lenacapavir
Medically reviewed by Drugs.com. Last updated on Jan 5, 2025.
Note: This document provides detailed information about Yeztugo Side Effects associated with lenacapavir. Some dosage forms listed on this page may not apply specifically to the brand name Yeztugo.
Applies to lenacapavir: oral tablet.
Other dosage forms:
Precautions
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Do not use this medicine together with carbamazepine (Tegretol®), phenytoin (Dilantin®), rifampin (Rifadin®), or St. John’s wort.
Your immune system may get stronger when you start using HIV medicines. Tell your doctor right away if you notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, including pneumonia, herpes, or tuberculosis. Autoimmune disorders (eg, Graves disease, polymyositis, and Guillain-Barré syndrome) may also occur.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of Yeztugo
Along with its needed effects, lenacapavir (the active ingredient contained in Yeztugo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lenacapavir:
Incidence not known
- dark urine
- fever
- inability to move the arms and legs
- joint pain
- light-colored stools
- muscle tenderness, weakness, or pain
- nausea and vomiting
- skin rash
- sudden numbness and weakness in the arms and legs
- unusual tiredness or weakness
- upper right abdominal or stomach pain
- weight loss
- yellow eyes and skin
See also:
Descovy
Descovy is used to treat and prevent HIV infection in adults and adolescents. When used for HIV-1 ...
Truvada
Truvada is used to prevent HIV (HIV PrEP) or treat HIV-1 infection in combination with other HIV-1 ...
Botox
Botox is used cosmetically to reduce facial lines and wrinkles and for medical purposes for ...
Apretude
Apretude is used to prevent HIV (HIV PrEP) in adults and adolescents weighing at least 77 pounds ...
Sunlenca
Sunlenca (lenacapavir) is used for the treatment of HIV-1 infection in heavily ...
Vocabria
Vocabria (cabotegravir) is used in the treatment of HIV-1 infection in adults. Includes Vocabria ...
AccessPak for HIV PEP Basic
AccessPak for HIV PEP Basic is used for HIV Infection, nonoccupational exposure, occupational ...
Cabotegravir
Cabotegravir is an antiviral medication used for the prevention and treatment of HIV. Brand names ...
Emtricitabine/tenofovir disoproxil
Emtricitabine/tenofovir disoproxil (brand name Truvada) is a combination antiviral tablet that may ...
For healthcare professionals
Applies to lenacapavir: oral tablet, subcutaneous solution.
General adverse events
The most common adverse reactions reported in at least 3% patients were nausea and injection site reactions.[Ref]
Gastrointestinal
- Common (1% to 10%): Nausea[Ref]
Hepatic
- Common (1% to 10%): Increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased direct bilirubin[Ref]
Local
- Very common (10% or more): Injection site reactions (65%) [include swelling (36%), pain (31%), erythema (31%), nodule (25%), induration (15%), pruritus (6%), extravasation (3%) discomfort (1%), mass (3%), hematoma (1%), edema (1%) and ulcer (1%)][Ref]
Four percent patients experienced Grade 3 ISRs (erythema, pain, swelling)[Ref]
Metabolic
- Common (1% to 10%): Glycosuria, hyperglycemia, proteinuria[Ref]
Musculoskeletal
- Very common (10% or more): Increased creatinine (13%)[Ref]
References
1. (2022) "Product Information. Sunlenca (lenacapavir)." Gilead Sciences
2. (2023) "Product Information. Sunlenca (lenacapavir)." Gilead Sciences Pty Ltd, SUNLENCA Product Inf
More about Yeztugo (lenacapavir)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Drug images
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: miscellaneous antivirals
- Breastfeeding
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
Further information
Yeztugo side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.