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Telzir Side Effects

Generic name: fosamprenavir

Medically reviewed by Drugs.com. Last updated on Apr 22, 2024.

Note: This document provides detailed information about Telzir Side Effects associated with fosamprenavir. Some dosage forms listed on this page may not apply specifically to the brand name Telzir.

Applies to fosamprenavir: oral suspension, oral tablet.

Serious side effects of Telzir

Along with its needed effects, fosamprenavir (the active ingredient contained in Telzir) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fosamprenavir:

More common

  • black, tarry stools
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • skin rash
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Incidence not known

  • blistering, peeling, loosening of the skin
  • blood in the urine
  • chest pain or discomfort
  • diarrhea
  • itching
  • joint or muscle pain
  • large amount of cholesterol in the blood
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • nausea
  • pain in the groin or genitals
  • pain or discomfort in the arms, jaw, back, or neck
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sharp back pain just below the ribs
  • sweating
  • vomiting

Other side effects of Telzir

Some side effects of fosamprenavir may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • headache
  • stomach pain

Incidence not known

  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings in the mouth

For healthcare professionals

Applies to fosamprenavir: oral suspension, oral tablet.

General

Diarrhea, rash, nausea, vomiting, and headache were the most frequent moderate to severe side effects in clinical trials. Discontinuations due to side effects were 6.4% in patients using this drug compared to 5.9% in those using comparator therapies; the most common side effects leading to discontinuation of this drug (incidence up to 1%) included diarrhea, nausea, vomiting, increased AST, increased ALT, and rash.[Ref]

Dermatologic

Protease inhibitors:

Skin rash (regardless of causality) was reported in about 19% of patients. Rashes were generally maculopapular and of mild or moderate intensity, some with pruritus. Rash had a median onset and duration of 11 and 13 days, respectively, and led to discontinuation of this drug in less than 1% of patients.[Ref]

Gastrointestinal

Increased serum lipase (greater than 2 times the upper limit of normal [2 x ULN]) has been reported in up to 8% of patients.

Vomiting was reported more often in pediatric patients than adult patients.[Ref]

Other

Antiretroviral therapy:

Increased fasting triglycerides (greater than 750 mg/dL) have been reported in up to 11% of patients.[Ref]

Hepatic

Elevated ALT (greater than 5 x ULN) and AST (greater than 5 x ULN) have been reported in up to 8% and up to 6% of patients, respectively.[Ref]

Hematologic

Amprenavir:

Protease inhibitors:

Decreased absolute neutrophil count (less than 750 cells/mm3) has been reported in 3% of patients.

Neutropenia was reported more often in pediatric patients than adult patients.[Ref]

Metabolic

Protease inhibitors:

Antiretroviral therapy:

Increased glucose (greater than 251 mg/dL) has been reported in 2% of patients.[Ref]

Nervous system

Hypersensitivity

Cardiovascular

Renal

Musculoskeletal

Protease inhibitors:

Psychiatric

Immunologic

References

1. Warnke D, Barreto J, Temesgen Z (2007) "Antiretroviral drugs." J Clin Pharmacol, 47, p. 1570-9

2. (2009) "Drugs for HIV infection." Treat Guidel Med Lett, 7, p. 11-22

3. Panel on Antiretroviral Therapy and Medical Management of Children Living with HIV (2018) Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. https://aidsinfo.nih.gov/contentfiles/lvguidelines/pediatricguidelines.pdf

4. Panel on Antiretroviral Guidelines for Adults and Adolescents (2018) Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV. https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf

5. (2003) "Product Information. Lexiva (fosamprenavir)." GlaxoSmithKline

6. Gathe JC Jr, Ive P, Wood R, et al. (2004) "SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir /ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients." AIDS, 18, p. 1529-1537

7. Shelton MJ, Wire MB, Lou Y, Adamkiewicz B, Min SS (2006) "Pharmacokinetic and safety evaluation of high-dose combinations of fosamprenavir and ritonavir." Antimicrob Agents Chemother, 50, p. 928-34

8. Wire MB, Baker KL, Jones LS, et al. (2006) "Ritonavir Increases Plasma Amprenavir (APV) Exposure to a Similar Extent when Coadministered with either Fosamprenavir or APV." Antimicrob Agents Chemother, 50, p. 1578-80

9. Hester EK, Chandler HV, Sims KM (2006) "Fosamprenavir: drug development for adherence." Ann Pharmacother, 40, p. 1301-10

10. Piacenti FJ (2006) "An update and review of antiretroviral therapy." Pharmacotherapy, 26, p. 1111-33

11. Eron J Jr, Yeni P, Gathe J Jr, et al. (2006) "The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection over 48 weeks: a randomised non-inferiority trial." Lancet, 368, p. 476-82

12. Ruane PJ, Luber AD, Wire MB, et al. (2006) "Plasma amprenavir pharmacokinetics and tolerability following administration of 1,400 milligrams fosamprenavir once daily in combination with either 100 OR 200 milligrams of ritonavir in healthy volunteers." Antimicrob Agents Chemother, 51, p. 560-5

13. Pavel S, Burty C, Alcaraz I, et al. (2007) "Severe liver toxicity in postexposure prophylaxis for HIV infection with a zidovudine, lamivudine and fosamprenavir/ritonavir regimen." AIDS, 21, p. 268-269

14. Borras-Blasco J, Navarro-Ruiz A, Borras C, Castera E (2008) "Adverse cutaneous reactions associated with the newest antiretroviral drugs in patients with human immunodeficiency virus infection." J Antimicrob Chemother, 62, p. 879-88

15. Arvieux C, Tribut O (2005) "Amprenavir or Fosamprenavir plus Ritonavir in HIV Infection: Pharmacology, Efficacy and Tolerability Profile." Drugs, 65, p. 633-59

16. Gathe JC Jr, Wood R, Sanne I, et al. (2006) "Long-Term (120-Week) antiviral efficacy and tolerability of fosamprenavir/ritonavir once daily in therapy-naive patients with HIV-1 infection: An uncontrolled, open-label, single-arm follow-on study." Clin Ther, 28, p. 745-54

17. Soriano V, Puoti M, Sulkowski M, et al. (2007) "Care of patients coinfected with HIV and hepatitis C virus: 2007 updated recommendations from the HCV-HIV International Panel." AIDS, 21, p. 1073-89

18. Bergersen BM (2006) "Cardiovascular Risk in Patients with HIV Infection : Impact of Antiretroviral Therapy." Drugs, 66, p. 1971-87

19. Calza L, Manfredi R, Verucchi G (2010) "Myocardial infarction risk in HIV-infected patients: epidemiology, pathogenesis, and clinical management." AIDS, 24, p. 789-802

Further information

Telzir side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.