Telotristat Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 25, 2024.

Applies to telotristat: oral tablet.

Common side effects of telotristat

Some side effects of telotristat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• bloating or swelling of the face, arms, hands, lower legs, or feet
• decreased appetite
• discouragement
• excess air or gas in the stomach or intestines
• feeling sad or empty
• fever
• full feeling
• headache
• irritability
• lack of appetite
• loss of interest or pleasure
• nausea
• passing gas
• rapid weight gain
• tingling of the hands or feet
• tiredness
• trouble concentrating
• trouble sleeping
• unusual weight gain or loss

Serious side effects of telotristat

Along with its needed effects, telotristat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking telotristat:

Incidence not known

• severe constipation
• severe stomach pain

For healthcare professionals

Applies to telotristat: oral tablet.

General adverse events

The most commonly reported side effects included abdominal pain, increased GGT, nausea, and/or headaches.^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal pain (up to 26%), nausea (up to 13%)
• Common (1% to 10%): Abdominal distention, constipation, flatulence
• Frequency not reported: Gastrointestinal pain, lower abdominal pain, serious constipation, upper abdominal pain^[Ref]

Hepatic

• Very common (10% or more): Increased GGT (up to 11%)
• Common (1% to 10%): ALT increased, AST increased, blood alkaline phosphatase increased
• Frequency not reported: GGT, liver enzymes increased, liver function test abnormal^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 11%)^[Ref]

Psychiatric

• Common (1% to 10%): Depressed mood, depression
• Frequency not reported: Decreased interest^[Ref]

Other

• Common (1% to 10%): Fatigue, pyrexia^[Ref]

Cardiovascular

• Common (1% to 10%): Peripheral edema^[Ref]

Metabolic

• Common (1% to 10%): Decreased appetite^[Ref]

Frequently asked questions

• What type of diarrhea does Xermelo treat?

Further information

Telotristat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer