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Telotristat Side Effects

Medically reviewed by Last updated on Apr 25, 2022.


Commonly reported side effects of telotristat include: constipation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to telotristat: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, telotristat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking telotristat:

Incidence not known

Side effects not requiring immediate medical attention

Some side effects of telotristat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • decreased appetite
  • discouragement
  • excess air or gas in the stomach or intestines
  • feeling sad or empty
  • fever
  • full feeling
  • headache
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • nausea
  • passing gas
  • rapid weight gain
  • tingling of the hands or feet
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • unusual weight gain or loss

For Healthcare Professionals

Applies to telotristat: oral tablet


The most commonly reported side effects included abdominal pain, increased GGT, nausea, and/or headaches.[Ref]


Very common (10% or more): Abdominal pain (up to 26%), nausea (up to 13%)

Common (1% to 10%): Abdominal distention, constipation, flatulence

Frequency not reported: Gastrointestinal pain, lower abdominal pain, serious constipation, upper abdominal pain[Ref]


Very common (10% or more): Increased GGT (up to 11%)

Common (1% to 10%): ALT increased, AST increased, blood alkaline phosphatase increased

Frequency not reported: GGT, liver enzymes increased, liver function test abnormal[Ref]

Nervous system

Very common (10% or more): Headache (up to 11%)[Ref]


Common (1% to 10%): Depressed mood, depression

Frequency not reported: Decreased interest[Ref]


Common (1% to 10%): Fatigue, pyrexia[Ref]


Common (1% to 10%): Peripheral edema[Ref]


Common (1% to 10%): Decreased appetite[Ref]

Frequently asked questions


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Xermelo (telotristat ethyl)." Lexicon Pharmaceuticals, Inc. (2017):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.