Telotristat ethyl (Oral)
Medically reviewed by Drugs.com. Last updated on Apr 14, 2022.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antidiarrheal
Uses for telotristat ethyl
Telotristat ethyl is used in combination with somatostatin analog (SSA) therapy to treat carcinoid syndrome diarrhea. Telotristat ethyl is used in adults who have received SSA therapy but did not work well.
Telotristat ethyl is available only with your doctor's prescription.
Before using telotristat ethyl
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For telotristat ethyl, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to telotristat ethyl or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of Xermelo™ in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Xermelo™ in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking telotristat ethyl, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using telotristat ethyl with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Proper use of telotristat ethyl
Take telotristat ethyl exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Take telotristat ethyl with food.
If you are using telotristat ethyl with short-acting octreotide, use it at least 30 minutes after taking Xermelo™.
The dose of telotristat ethyl will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of telotristat ethyl. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets)
- For treatment of carcinoid syndrome diarrhea:
- Adults—250 milligrams (mg) 3 times a day.
- Children—Use and dose must be determined by your doctor.
- For treatment of carcinoid syndrome diarrhea:
If you miss a dose of telotristat ethyl, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions while using telotristat ethyl
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
Call your doctor right away if you have severe constipation, or severe persistent or worsening stomach pain after taking telotristat ethyl.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Telotristat ethyl side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
- Severe constipation
- severe stomach pain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- decreased appetite
- excess air or gas in the stomach or intestines
- feeling sad or empty
- full feeling
- lack of appetite
- loss of interest or pleasure
- passing gas
- rapid weight gain
- tingling of the hands or feet
- trouble concentrating
- trouble sleeping
- unusual weight gain or loss
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Frequently asked questions
More about telotristat
- Side effects
- Drug interactions
- Dosage information
- During pregnancy
- Reviews (1)
- En español
- Drug class: miscellaneous GI agents
- Other brands
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.